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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Jakob, T., Blank, S. & Spillner, E. (2017). Benefits and limitations of recombinant allergens in diagnostics of insect venom allergy. In J. Kleine-Tebbe & T. Jakob (Eds.), Molecular Allergy Diagnostics: Innovation for a Better Patient Management (pp. 341-362). Springer. https://doi.org/10.1007/978-3-319-42499-6_18

Otzen, D. (2017). Biosurfactants and surfactants interacting with membranes and proteins: Same but different? Biochimica et biophysica acta - Biomembranes, 1859(4), 639–649. https://doi.org/10.1016/j.bbamem.2016.09.024

Lyons, J. A. & Nissen, P. (2017). Brief encounters of cytochrome c. EMBO Journal, 36(3), 250-251. https://doi.org/10.15252/embj.201696124

Nielsen, H. & Nielsen, K. H. (2017). "Byen under isen" gav politikerne spændte nerver. Kristeligt Dagblad, 7.

Nielsen, H. & Nielsen, K. H. (2017, Dec 18). Camp Century: Den hemmelige by under Grønlands indlandsis. https://videnskab.dk/kultur-samfund/camp-century-byen-under-groenlands-indlandsis

Nielsen, H. & Nielsen, K. H. (2017). Camp Century - en "varm kartoffel" fra den kolde krig. Aktuel Naturvidenskab, 6, 38-41.

Nielsen, H. & Nielsen, K. H. (2017). Camp Century. Koldkrigsbyen under Grønlands indlandsis. Aarhus Universitetsforlag.

Nielsen, K. H. (2017). Camp Century's Degrees of Coldness: From Cold War Icon to Climate Change-Induced Problem. Nach Feierabend. Zürcher Jahrbuch für Wissensgeschichte, 13, 17-37.

Okholm, T. L. H., Nielsen, M. M., Hamilton, M., Christensen, L.-L., Vang, S., Hedegaard, J., Hansen, T. B., Kjems, J., Dyrskjøt, L. & Pedersen, J. S. (2017). Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer. npj Genomic Medicine, 2(1), Article 36. https://doi.org/10.1038/s41525-017-0038-z

Yan, Y., Wang, X., Venø, M. T., Bakholdt, V., Sørensen, J. A., Krogdahl, A., Sun, Z., Gao, S. & Kjems, J. (2017). Circulating miRNAs as biomarkers for oral squamous cell carcinoma recurrence in operated patients. OncoTarget, 8(5), 8206-8214. https://doi.org/10.18632/oncotarget.14143

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Kalinka Hansen