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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Bailey, M. H., Meyerson, W. U., Dursi, L. J., Wang, L. B., Dong, G., Liang, W. W., Weerasinghe, A., Li, S., Kelso, S., Akbani, R., Anur, P., Bailey, M. H., Buchanan, A., Chiotti, K., Covington, K., Creason, A., Ding, L., MC3 Working Group, PCAWG novel somatic mutation calling methods working group & PCAWG Consortium (2020). Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nature Communications, 11(1), Article 4748. https://doi.org/10.1038/s41467-020-18151-y

Wang, Z., Wu, H. H., Li, Q., Besenbacher, F., Li, Y., Zeng, X. C. & Dong, M. (2020). Reversing Interfacial Catalysis of Ambipolar WSe₂ Single Crystal. Advanced Science, 7(3), Article 1901382. https://doi.org/10.1002/advs.201901382

Schiølin, K. (2020). Revolutionary dreams: Future essentialism and the sociotechnical imaginary of the fourth industrial revolution in Denmark. Social Studies of Science, 50(4), 542-566. https://doi.org/10.1177/0306312719867768

Nielsen, K. H. (2020). Science communication from the perspective of STS. In A. Turanlı, A. U. Aydınoğlu & M. Şahinol (Eds.), Türkiye’de STS: bilim ve teknoloji Çalışmalarına giriş (pp. 37-47). İstanbul Teknik Üniversitesi. http://hdl.handle.net/11527/18483

Krainer, G., Hartmann, A., Bogatyr, V., Nielsen, J., Schlierf, M. & Otzen, D. E. (2020). SDS-induced multi-stage unfolding of a small globular protein through different denatured states revealed by single-molecule fluorescence. Chemical Science, 11(34), 9141-9153. https://doi.org/10.1039/d0sc02100h

Li, C. H., Prokopec, S. D., Sun, R. X., Yousif, F., Schmitz, N., PCAWG Tumour Subtypes and Clinical Translation, Boutros, P. C. & PCAWG Consortium (2020). Sex differences in oncogenic mutational processes. Nature Communications, 11, Article 4330. https://doi.org/10.1038/s41467-020-17359-2

Chen, M. (2020). She’s injecting ‘solar cells’ into the body to regenerate brain cells. In J. Bruun (Ed.), Profile 2020 (pp. 70-73). Aarhus Universitet, Institut for Ingeniørvidenskab . https://www.e-pages.dk/aarhusuniversitet/2231/html5/

Nielsen, K. H. (2020). Singularitet. Weekendavisen, (Sektion 4 (Ideer)), 10.