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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Nielsen, K. H. (2017). Allergi. Weekendavisen, Sektion 4 (Ideer), 10.

Jensen-Jarolim, E., Bax, HJ., Bianchini, R., Capron, M., Corrigan, C., Castells, M., Dombrovicz, D., Daniels-Wells, HR., Fazekas, J., Fiebiger, E., Gatault, S., Gould, H., Janda, J., Josephs, DH., Karagiannis, P., Levi-Schaffer, F., Meshcheryakova, A., Mechtcheriakova, D., Mekori, Y. ... Karagiannis, S. N. (2017). AllergoOncology - the Impact of Allergy in Oncology. EAACI Position Paper. Allergy: European Journal of Allergy and Clinical Immunology, 72(6), 866-887. https://doi.org/10.1111/all.13119

Nielsen, K. H. (2017, Feb 5). Alt det, vi ved, vi ikke ved - og alt det, vi ikke ved, vi ikke ved. Videnskab.dk. https://videnskab.dk/kultur-samfund/der-er-det-vi-ved-vi-ikke-ved-og-saa-er-der-alt-det-vi-ikke-ved-vi-ikke-ved

Rajman, M., Metge, F., Fiore, R., Khudayberdiev, S., Aksoy-Aksel, A., Bicker, S., Reschke, C. R., Raoof, R., Brennan, G. P., Delanty, N., Farrell, M. A., O'Brien, D. F., Bauer, S., Norwood, B., Veno, M. T., Krueger, M., Braun, T., Kjems, J., Rosenow, F. ... Schratt, G. (2017). A microRNA-129-5p/Rbfox crosstalk coordinates homeostatic downscaling of excitatory synapses. EMBO Journal, 36(12), 1770-1787. https://doi.org/10.15252/embj.201695748

Uhd, J., Okholm, A., Kjems, J. & Astakhova, K. (2017). Amplification-free liquid biopsy by fluorescence approach. In Biotech, Biomaterials and Biomedical - TechConnect Briefs 2017 (Vol. 3, pp. 106-109). TechConnect. https://briefs.techconnect.org/wp-content/volumes/TCB2017v3/pdf/762.pdf

Kuhlmann, M., Hamming, J. B. R., Voldum, A., Tsakiridou, G., Larsen, M. T., Schmøkel, J., Sohn, E., Bienk, K., Schaffert, D. H., Sørensen, E. S., Wengel, J., Dupont, D. M. & Howard, K. (2017). An albumin-oligonucleotide assembly for potential combinatorial drug delivery and half-life extension applications. Molecular Therapy - Nucleic Acids, 9, 284-293. https://doi.org/10.1016/j.omtn.2017.10.004

Schrempf, D. & Hobolth, A. (2017). An alternative derivation of the stationary distribution of the multivariate neutral Wright–Fisher model for low mutation rates with a view to mutation rate estimation from site frequency data. Theoretical Population Biology, 114, 88-94. https://doi.org/10.1016/j.tpb.2016.12.001

Rouse, S. L., Hawthorne, W. J., Berry, J.-L., Chorev, D. S., Ionescu, S. A., Lambert, S., Stylianou, F., Ewert, W., Mackie, U., Morgan, R. M. L., Otzen, D., Herbst, F.-A., Nielsen, P. H., Dueholm, M., Bayley, H., Robinson, C. V., Hare, S. & Matthews, S. (2017). A new class of hybrid secretion system is employed in Pseudomonas amyloid biogenesis. Nature Communications, 8(1), Article 263. https://doi.org/10.1038/s41467-017-00361-6