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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Høiberg, H. C., Sparvath, S. M., Andersen, V. L., Kjems, J. & Andersen, E. S. (2019). An RNA origami octahedron with intrinsic siRNAs for potent gene knockdown. Biotechnology Journal, 14(1), Article 1700634. https://doi.org/10.1002/biot.201700634

Subbiahdoss, G., Zeng, G., Aslan, H., Ege Friis, J., Iruthayaraj, J., Zelikin, A. N. & Meyer, R. L. (2019). Antifouling properties of layer by layer DNA coatings. Biofouling, 35(1), 75-88. https://doi.org/10.1080/08927014.2019.1568417

Mohammad-Beigi, H., Kjær, L., Eskandari, H., Aliakbari, F., Christiansen, G., Ruvo, G., L. Ward, J. & Otzen, D. (2019). A Possible Connection Between Plant Longevity and the Absence of Protein Fibrillation: Basis for Identifying Aggregation Inhibitors in Plants. Frontiers in Plant Science, 10(148), Article 148. https://doi.org/10.3389/fpls.2019.00148

Andersen, V. L., Vinther, M., Kumar, R., Ries, A., Wengel, J., Nielsen, J. S. & Kjems, J. (2019). A self-assembled, modular nucleic acid-based nanoscaffold for multivalent theranostic medicine. Theranostics, 9(9), 2662-2677. https://doi.org/10.7150/thno.32060

Nielsen, K. H. (2019). Aspergers' nazistiske rødder: Måske skulle vi give diagnosen et andet navn. Avisen Danmark.

Najarzadeh, Z., Pedersen, J. N., Christiansen, G., Shojaosadati, S. A., Pedersen, J. S. & Otzen, D. E. (2019). Bacterial amphiphiles as amyloid inducers: Effect of Rhamnolipid and Lipopolysaccharide on FapC fibrillation. Biochimica et Biophysica Acta - Proteins and Proteomics, 1867(11), Article 140263. https://doi.org/10.1016/j.bbapap.2019.140263

Christensen, L. F. B., Schafer, N., Wolf-Perez, A., Madsen, D. J. & Otzen, D. E. (2019). Bacterial Amyloids: Biogenesis and Biomaterials. In S. Perrett, A. K. Buell & T. P. J. Knowles (Eds.), Advances in Experimental Medicine and Biology (pp. 113-159). Springer. https://doi.org/10.1007/978-981-13-9791-2_4

Nielsen, K. H. (2019). Beatnik. Weekendavisen, Sektion 4 (Ideer), 10.

Nielsen, K. H. (2019). Beton. Weekendavisen, Sektion 4 (Ideer), 10.

Chen, Y., Taskin, M. B., Zhang, Z., Su, Y., Han, X. & Chen, M. (2019). Bioadhesive anisotropic nanogrooved microfibers directing three-dimensional neurite extension. Biomaterials Science, 7, 2165-2173. https://doi.org/10.1039/c8bm01603h

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Kalinka Hansen