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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Camilli, L., Jorgensen, J. H., Tersoff, J., Stoot, A. C., Balog, R., Cassidy, A., Sadowski, J. T., Boggild, P. & Hornekaer, L. (2017). Erratum: Self-assembly of ordered graphene nanodot arrays (vol 8, 47, 2017). Nature Communications, 8, Article 1155. https://doi.org/10.1038/s41467-017-00725-y

Nielsen, K. H. (2017). Evidens. Weekendavisen, Sektion 4 (Ideer), 10.

Bortolini, C., Liu, L., Hoffmann, S. V., Jones, N. C., Knowles, T. P. J. & Dong, M. (2017). Exciton Coupling of Phenylalanine Reveals Conformational Changes of Cationic Peptides. ChemistrySelect, 2(8), 2476-2479. https://doi.org/10.1002/slct.201601916

Greisen, S. R., Yan, Y., Hansen, A. S., Veno, M. T., Nyengaard, J. R., Moestrup, S. K., Hvid, M., Freeman, G. J., Kjems, J. & Deleuran, B. (2017). Extracellular Vesicles Transfer the Receptor Programmed Death-1 in Rheumatoid Arthritis. Frontiers in Immunology, 8(JUL), Article 851. https://doi.org/10.3389/fimmu.2017.00851

Xia, D., Luo, Y., Li, Q., Xue, Q., Zhang, X., Liang, C. & Dong, M. (2017). Extracting the inner wall from nested double-walled carbon nanotube by platinum nanowire: Molecular dynamics simulations. RSC Advances, 7(63), 39480-39489. https://doi.org/10.1039/c7ra07066g

Nielsen, K. H. (2017). Fakta. Weekendavisen, Sektion 4 (Ideer), 10.

Nielsen, K. H. (2017). Falske nyheder. Weekendavisen, Sektion 4 (Ideer), 10.

Hvam, M. L., Cai, Y., Dagnæs-Hansen, F., Nielsen, J., Wengel, J., Kjems, J. & Howard, K. (2017). Fatty acid-modified gapmer antisense oligonucleotide and human serum albumin constructs for pharmacokinetic modulation. Molecular Therapy, 25(7), 1710-1717. https://doi.org/10.1016/j.ymthe.2017.05.009

Nielsen, K. H. (2017). Forkølelse. Weekendavisen, Sektion 4 (Ideer), 10.

Nielsen, K. H. (2017, Apr 19). Forskningen har brug for dig! http://sciencereport.dk/meninger/forskningen-har-brug-dig/

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Kalinka Hansen