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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Nielsen, K. H. (2017). PC. Weekendavisen, Sektion 4 (Ideer), 10.

Blans, K. I. M., Hansen, M. S., Sørensen, L. V., Hvam, M. L., Howard, K., Möller, A., Wiking, L., Larsen, L. B. & Rasmussen, J. T. (2017). Pellet-free isolation of human and bovine milk extracellular vesicles by size-exclusion chromatography. Journal of Extracellular Vesicles, 6(1), Article 1294340. https://doi.org/10.1080/20013078.2017.1294340

Hirsch, C., Brereton, T. & Schmidt, V. (2017). Percolation and convergence properties of graphs related to minimal spanning forests. Electronic Journal of Probability, 22, 1-21.

Nielsen, K. H. (2017). Personlighed. Weekendavisen, Sektion 4 (Ideer), 10.

Feng, Y., Liu, L., Zhang, J., Aslan, H. & Dong, M. (2017). Photoactive antimicrobial nanomaterials. Journal of Materials Chemistry B, 5(44), 8631-8652. https://doi.org/10.1039/C7TB01860F

Zhang, Y., Schattling, P., Itel, F. R. & Stadler, B. M. (2017). Planar and Cell Aggregate-Like Assemblies Consisting of Microreactors and HepG2 Cells. ACS Omega, 2(10), 7085–7095. https://doi.org/10.1021/acsomega.7b01234

Basse-O'Connor, A., Lachieze-Rey, R. & Podolskij, M. (2017). Power variation for a class of stationary increments Levy driven moving averages. Annals of Probability, 45(6B), 4477-4528. https://doi.org/10.1214/16-AOP1170

Søndergaard, D., Nielsen, S., Pedersen, C. N. S. & Besenbacher, S. (2017). Prediction of Primary Tumors in Cancers of Unknown Primary. Journal of integrative bioinformatics, 14(2). https://doi.org/10.1515/jib-2017-0013

Madsen, M., Christensen , R. S., Krissanaprasit, A., Bakke, M. R., Riber, C. F., Nielsen , K. S., Zelikin, A. N. & Gothelf, K. V. (2017). Preparation, single-molecule manipulation and energy transfer investigation of a polyfluorene-graft-DNA polymer. Chemistry: A European Journal, 23(44), 10511-10515. https://doi.org/10.1002/chem.201702780

Walther, R., Rautio, J. & Zelikin, A. N. (2017). Prodrugs in medicinal chemistry and enzyme prodrug therapies. Advanced Drug Delivery Reviews, 118(september), 65-77. https://doi.org/10.1016/j.addr.2017.06.013

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Kalinka Hansen