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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Risør, M. W., Juhl, D. W., Bjerring, M., Mathiesen, J., Enghild, J. J., Nielsen, N. C. & Otzen, D. E. (2017). Critical Influence of Cosolutes and Surfaces on the Assembly of Serpin-Derived Amyloid Fibrils. Biophysical Journal, 113(3), 580-596. https://doi.org/10.1016/j.bpj.2017.06.030

Kang, R., Li, H., Lysdahl, H., Quang Svend Le, D., Chen, M., Xie, L. & Bünger, C. (2017). Cyanoacrylate medical glue application in intervertebral disc annulus defect repair: Mechanical and biocompatible evaluation. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 105(1), 14–20 . https://doi.org/10.1002/jbm.b.33524

Nielsen, K. H. (2017, Jun 28). Dannelse kan give mindre uredelig forskning.

Jakob, T., Rafei-Shamsabadi, D., Spillner, E. & Müller, S. (2017). Diagnostics in hymenoptera venom allergy: Current concepts and developments with special focus on molecular allergy diagnostics. Allergo Journal International, 26(3), 93-105. https://doi.org/10.1007/s40629-017-0014-2

Schmidt, E. G. W., Hvam, M. L., Antunes, F., Cameron, J., Viuff, D., Andersen, B., Kristensen, N. N. & Howard, K. A. (2017). Direct demonstration of a neonatal Fc receptor (FcRn)-driven endosomal sorting pathway for cellular recycling of albumin. Journal of Biological Chemistry, 292(32), 13312-13322. https://doi.org/10.1074/jbc.M117.794248

Froning, J. P., Lazar, P., Pykal, M., Li, Q., Dong, M., Zbořil, R. & Otyepka, M. (2017). Direct mapping of chemical oxidation of individual graphene sheets through dynamic force measurements at the nanoscale. Nanoscale, 9(1), 119-127. https://doi.org/10.1039/c6nr05799c

Brodersen, D. E., Bendtsen, K. L., Xu, K., Luckmann, M., Winther, K., Shah, S. A. & Pedersen, C. N. S. (2017). Discrete Structural Dynamics of Pseudo-Palindromic Motifs Control DNA Binding of Bacterial Toxin-Antitoxin Complexes. The FASEB Journal, 31(No. 1 supplement), Article 777.2. http://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.777.2

Thorup, C., Schramm, A., Findlay, A. J. L., Finster, K. & Schreiber, L. (2017). Disguised as a sulfate reducer: Growth of the Deltaproteobacterium Desulfurivibrio alkaliphilus by Sulfide Oxidation with Nitrate. mBio (Online), 8(4), Article e00671-17. https://doi.org/10.1128/ mBio.00671-17

Nielsen, K. H. (2017). Disruption. Weekendavisen, Sektion 4 (Ideer), 10.

Schattling, P., Ramos-Docampo, M., Salgueiriño, V. & Stadler, B. M. (2017). Double-Fueled Janus Swimmers with Magnetotactic Behavior. ACS Nano, 11(4), 3973–3983. https://doi.org/10.1021/acsnano.7b00441

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Kalinka Hansen