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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Xu, R., Zhao, H., Muhammad, H., Dong, MD., Besenbacher, F. & Chen, M. (2017). Dual-delivery of FGF-2/CTGF from Silk Fibroin/PLCL-PEO Coaxial Fibers Enhances MSC Proliferation and Fibrogenesis. Scientific Reports, 7(1), 8509. Article 8509. https://doi.org/10.1038/s41598-017-08226-0

Dyla, M., Terry, D., Kjærgaard, M., Sørensen, T. L.-M., Andersen, J. L., Andersen, J. P., Knudsen, C. R., Altman, R., Nissen, P. & Blanchard, S. (2017). Dynamics of P-type ATPase transport cycle revealed by single-molecule FRET. Nature, 551(7680), 346-351. https://doi.org/10.1038/nature24296

Ma, M., Hansen, H. A., Valenti, M., Wang, Z., Cao, A., Dong, M. & Smith, W. A. (2017). Electrochemical reduction of CO₂ on compositionally variant Au-Pt bimetallic thin films. Nano Energy, 42, 51-57. https://doi.org/10.1016/j.nanoen.2017.09.043, https://doi.org/10.1016/j.nanoen.2017.09.043

Bak, E. N., Jones, E., Yde, J. C., Hodson, A., Mallon, G. & Finster, K. (2017). Electron acceptor-based regulation of microbial greenhouse gas production from thawing permafrost. Poster session presented at EGU 2017, Wien, Austria.

Nielsen, K. H. (2017). Encyklopædi. Weekendavisen, Sektion 4 (Ideer), 10.

Grossi, G., Jaekel, A., Andersen, E. S. & Sacca, B. (2017). Enzyme-functionalized DNA nanostructures as tools for organizing and controlling enzymatic reactions. MRS Bulletin, 42(12), 920-924. https://doi.org/10.1557/mrs.2017.269

Städler, B. & Zelikin, A. N. (2017). Enzyme prodrug therapies and therapeutic enzymes. Advanced Drug Delivery Reviews, 118(9). https://doi.org/10.1016/j.addr.2017.10.006

Chandrawati, R., Olesen, M. T. J., Marini, T. C. C., Bisra, G., Guex, A. G., de Oliveira, M. G., Zelikin, A. N. & Stevens, M. M. (2017). Enzyme Prodrug Therapy Engineered into Electrospun Fibers with Embedded Liposomes for Controlled, Localized Synthesis of Therapeutics. Advanced Healthcare Materials, 6(17), Article 1700385. https://doi.org/10.1002/adhm.201700385

Itel, F. R., Schattling, P., Zhang, Y. & Stadler, B. M. (2017). Enzymes as Key Features in Therapeutic Cell Mimicry. Advanced Drug Delivery Reviews, 118, 94-108. https://doi.org/10.1016/j.addr.2017.09.006

Nielsen, K. H. (2017). Episteme. Weekendavisen, Sektion 4 (Ideer), 10.

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Kalinka Hansen