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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Jakob, T., Müller, U., Helbling, A. & Spillner, E. (2017). Component resolved diagnostics for Hymenoptera venom allergy. Current Opinion in Allergy and Clinical Immunology, 17(5), 363-372. https://doi.org/10.1097/ACI.0000000000000390

Sparvath, S. L., Geary, C. W. & Andersen, E. S. (2017). Computer-aided design of RNA origami structures. Methods in Molecular Biology, 1500, 51-80. https://doi.org/10.1007/978-1-4939-6454-3_5

Manuguerra, I., Grossi, G., Thomsen, R. P., Lyngsø, J., Pedersen, J. S., Kjems, J., Andersen, E. S. & Gothelf, K. V. (2017). Construction of a Polyhedral DNA 12-Arm Junction for Self-Assembly of Wireframe DNA Lattices. A C S Nano, 11(9), 9041-9047. https://doi.org/10.1021/acsnano.7b03538

Grossi, G., Jepsen, M. D. E., Kjems, J. & Andersen, E. S. (2017). Control of enzyme reactions by a reconfigurable DNA nanovault. Nature Communications, 8(1), Article 992. https://doi.org/10.1038/s41467-017-01072-8

Malmos, K. G., Bjerring, M., Jessen, C. M., Nielsen, E. H. T., Poulsen, E. T., Christiansen, G., Vosegaard, T., Skrydstrup, T., Enghild, J. J., Pedersen, J. S. & Otzen, D. E. (2017). Correction to: How glycosaminoglycans promote fibrillation of salmon calcitonin. Journal of Biological Chemistry, 292(38), 15992. https://doi.org/10.1074/jbc.A116.715466

Veno, M. T., Veno, S. T., Rehberg, K., van Asperen, J. V., Clausen, B. H., Holm, I. E., Pasterkamp, R. J., Finsen, B. & Kjems, J. (2017). Cortical Morphogenesis during Embryonic Development Is Regulated by miR-34c and miR-204. Frontiers in Molecular Neuroscience, 10(31), Article 31. https://doi.org/10.3389/fnmol.2017.00031

Risør, M. W., Juhl, D. W., Bjerring, M., Mathiesen, J., Enghild, J. J., Nielsen, N. C. & Otzen, D. E. (2017). Critical Influence of Cosolutes and Surfaces on the Assembly of Serpin-Derived Amyloid Fibrils. Biophysical Journal, 113(3), 580-596. https://doi.org/10.1016/j.bpj.2017.06.030

Kang, R., Li, H., Lysdahl, H., Quang Svend Le, D., Chen, M., Xie, L. & Bünger, C. (2017). Cyanoacrylate medical glue application in intervertebral disc annulus defect repair: Mechanical and biocompatible evaluation. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 105(1), 14–20 . https://doi.org/10.1002/jbm.b.33524

Nielsen, K. H. (2017, Jun 28). Dannelse kan give mindre uredelig forskning.

Jakob, T., Rafei-Shamsabadi, D., Spillner, E. & Müller, S. (2017). Diagnostics in hymenoptera venom allergy: Current concepts and developments with special focus on molecular allergy diagnostics. Allergo Journal International, 26(3), 93-105. https://doi.org/10.1007/s40629-017-0014-2

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Kalinka Hansen