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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Waltoft, B. L., Pedersen, C. B., Nyegaard, M. & Hobolth, A. (2015). The importance of distinguishing between the odds ratio and the incidence rate ratio in GWAS. BMC Medical Genetics, 16(1), 71. https://doi.org/10.1186/s12881-015-0210-1

Michaels, T. C. T., Yde, P., Willis, J. C. W., Jensen, M. H., Otzen, D., Dobson, C. M., Buell, A. K. & Knowles, T. P. J. (2015). The length distribution of frangible biofilaments. Journal of Chemical Physics, 143(16), 1-15. Article 164901. https://doi.org/10.1063/1.4933230

Frahm, H., Hansen, S. K., Vad, B. S., Nielsen, E. H., Nielsen, J. T., Vosegaard, T., Skrydstrup, T. & Otzen, D. E. (2015). The natural, peptaibolic peptide SPF-5506-A4 adopts a β-bend spiral structure, shows low hemolytic activity and targets membranes through formation of large pores. Biochimica et Biophysica Acta - Proteins and Proteomics, 1854(8), 882-889. https://doi.org/10.1016/j.bbapap.2015.03.003

Yang, C., Ogaki, R., Hansen, L., Kjems, J. & Mian Teo, B. (2015). Theranostic carbon dots derived from garlic with efficient anti-oxidative effects towards macrophages. R S C Advances, 118, 97836-97840. https://doi.org/10.1039/C5RA16874K

Wilton, P. R., Carmi, S. & Hobolth, A. (2015). The SMC' is a highly accurate approximation to the ancestral recombination graph. Genetics (Print), 200(1), 343-355. Article 1. http://intl.genetics.org/content/200/1/343.full

Hayes, S., Lewis, P., Islam, M. M., Doutch, J., Sorensen, T., White, T., Griffith, M. & Meek, K. M. (2015). The structural and optical properties of type III human collagen biosynthetic corneal substitutes. Acta Biomaterialia, 25, 121-30. https://doi.org/10.1016/j.actbio.2015.07.009

Dueholm, M. S., Larsen, P., Finster, K., Stenvang, M. R., Christiansen, G., Vad, B. S., Bøggild, A., Otzen, D. E. & Halkjær Nielsen, P. (2015). The Tubular Sheaths Encasing Methanosaeta thermophila Filaments are Functional Amyloids. Journal of Biological Chemistry, 290, 20590-26600. https://doi.org/10.1074/jbc.M115.654780

Pedersen, J. N., Pedersen, J. S. & Otzen, D. E. (2015). The Use of Liprotides To Stabilize and Transport Hydrophobic Molecules. Biochemistry, 54(31), 4815-4823. https://doi.org/10.1021/acs.biochem.5b00547

Abass, A., Hayes, S., White, N., Sorensen, T. & Meek, K. M. (2015). Transverse depth-dependent changes in corneal collagen lamellar orientation and distribution. Journal of the Royal Society. Interface, 12(104), 20140717. https://doi.org/10.1098/rsif.2014.0717

Whitehead, B. J., Wu, L., Hvam, M. L., Aslan, H., Dong, M., Dyrskjøt, L., Ostenfeld, M. S., Moein Moghimi, S. & Howard, K. (2015). Tumour exosomes display different differential mechanical and complement activation properties dependent on malignant state: implications in endothelial leakiness. Journal of Extracellular Vesicles, 4, Article 29685. https://doi.org/10.3402/jev.v4.29685

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Kalinka Hansen