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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Li, D., Dong, MD., Besenbacher, F., Huang, Y. & Chen, M. (2016). The preparation of a recyclable catalyst of silver nanoparticles dispersed in mesoporous silica nanofiber matrix. RSC Advances, 6(70), 65613 - 65618. https://doi.org/10.1039/C6RA10867A

Li, D., Dong, MD., Besenbacher, F., Huang, Y. & Chen, M. (2016). The preparation of a recyclable catalyst of silver nanoparticles dispersed in mesoporous silica nanofiber matrix. Journal of Biotechnology & Biomaterials, 6(3(Suppl)), 40-40. https://doi.org/10.4172/2155-952X.C1.052

Vu-Quang, H., Vinding, M. S., Nielsen, T., Ullisch, M. G., Nielsen, N. C. & Kjems, J. (2016). Theranostic Tumor Targeted Nanoparticles Combining Drug Delivery with Dual Near Infrared and (19)F Magnetic Resonance Imaging Modalities. Nanomedicine: Nanotechnology, Biology and Medicine, 12(7), 1873-1884. https://doi.org/10.1016/j.nano.2016.04.010

Ling, M., Santl-Temkiv, T., Holm, S., Finster, K. & Boesen, T. (2016). The role of ice nucleation protein in active atmospheric dissemination of P. syringae. Poster session presented at ISME Conference 2016, Montreal, Canada.

Agerschou, E. D., Christiansen, G., Schafer, N. P., Madsen, D. J., Brodersen, D. E., Semsey, S. & Otzen, D. E. (2016). The transcriptional regulator GalR self-assembles to form highly regular tubular structures. Scientific Reports, 6, Article 27672. https://doi.org/10.1038/srep27672

Xia, D., Zhang, S., Nielsen, E., Ivarsen, A. R., Liang, C., Li, Q., Thomsen, K., Hjortdal, J. Ø. & Dong, M. (2016). The Ultrastructures and Mechanical Properties of the Descement's Membrane in Fuchs Endothelial Corneal Dystrophy. Scientific Reports, 6, Article 23096. https://doi.org/10.1038/srep23096

Taskin, M. B., Xu, R., Gregersen, H. V., Nygaard, J. V., Besenbacher, F. & Chen, M. (2016). Three-dimensional polydopamine functionalized coiled microfibrous scaffolds enhance human mesenchymal stem cells colonization and mild myofibroblastic differentiation. A C S Applied Materials and Interfaces, 8(25), 15864–15873. https://doi.org/10.1021/acsami.6b02994

Nielsen, K. H. (2016). Tid. Weekendavisen, Ideer, 10.

Kryger, M. B. L., Pedersen, S. L., Wohl, B. M. & Zelikin, A. N. (2016). Tools of gene transfer applied to the intracellular delivery of non-nucleic acid polyanionic drugs. Chemical Communications, 52(5), 889-891. https://doi.org/10.1039/c5cc08011h

Nielsen, K. H. (2016). “Too obvious today”? Revisiting the web model of science communication. Paper presented at PCST 2016, Istanbul, Turkey. http://www.pcst.co/proposals/download_file.php?ip=365

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Kalinka Hansen