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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Coudrillier, B., Pijanka, J., Jefferys, J., Sorensen, T., Quigley, H. A., Boote, C. & Nguyen, T. D. (2015). Effects of age and diabetes on scleral stiffness. Journal of Biomechanical Engineering, 137(7). https://doi.org/10.1115/1.4029986

Jarczewska, M., Kekedy-Nagy, L., Nielsen, J. S., Campos, R., Kjems, J., Malinowska, E. & Ferapontova, E. E. (2015). Electroanalysis of pM-levels of urokinase plasminogen activator in serum by phosphorothioated RNA aptamer. Analyst, 140(11), 3794-3802. https://doi.org/10.1039/c4an02354d

Koefoed, L., Kongsfelt, M. S., Ulstrup, S., Grubisic Cabo, A., Cassidy, A., Whelan, P. R., Bianchi, M., Dendzik, M., Pizzocchero, F., Jørgensen, B., Bøggild, P., Hornekær, L., Hofmann, P., Pedersen, S. U. & Daasbjerg, K. (2015). Electrochemical Transfer of Large-Area Single Crystal Epitaxial Graphene from Ir(111). Poster session presented at Graphene 2015, Bilbao, Spain.

de Almeida Campos, R. C., Zhang, S., Majikes, J. M., Ferraz, L. C. C., LaBean, T. H., Dong, M. D. & Ferapontova, E. E. (2015). Electronically addressable nanomechanical switching of i-motif DNA origami assembled on basal plane HOPG. Chemical Communications, 51(74), 14111-14114. https://doi.org/10.1039/c5cc04678e

Prabha, R., Kraft, D. C. E., Melsen, B., Varma, H., Nair, P. D., Kjems, J. & Kassem, M. (2015). Electrospun PVA-PCL-HAB scaffold for craniofacial bone regeneration. Tissue Engineering. Part A, 21(Supplement 1), S-58. https://doi.org/10.1089/ten.tea.2015.5000.abstracts

Schattling, P., Thingholm, B. & Stadler, B. (2015). Enhanced Diffusion of Glucose-Fueled Janus Particles. Chemistry of Materials, 27(21), 7412-7418. https://doi.org/10.1021/acs.chemmater.5b03303

Sun, M., Yang, C., Zheng, J., Wang, M., Chen, M., Le, D. Q. S., Kjems, J. & Bünger, C. (2015). Enhanced efficacy of chemotherapy for breast cancer stem cells by simultaneous suppression of multidrug resistance and antiapoptotic cellular defense. Acta Biomaterialia, 28, 171–182. https://doi.org/10.1016/j.actbio.2015.09.029

Nielsen, K. H. (2015). En teknisk fejl skæmmede Danmarks første offentlige tv-transmission. Jyllands-Posten, 7. http://www.jyllands-posten.dk/protected/premium/indland/ECE8329291/1926-%E2%80%93-TV-En-teknisk-fejl-sk%C3%A6mmede-Danmarks-f%C3%B8rste-offentlige-tv-transmission/

Eriksen, C. B. (2015). Er kroppen blot en maskine ? Minutiøs materialitet hos René Descartes. Semikolon (Aarhus C), årg. 15 (28), 11-20.

Nielsen, M., Schreiber, L., Finster, K. & Schramm, A. (2015). Erratum to 'Draft genome sequence of Bacillus azotoformans MEV2011, a (Co-) denitrifying strain unable to grow with oxygen'. Standards in Genomic Sciences, 10(72). https://doi.org/10.1186/s40793-015-0057-2

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Kalinka Hansen