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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Cheng, W., Zhang, Z., Xu, R., Cai, P., Kristensen, P., Chen, M. & Huang, Y. (2018). Incorporation of bacteriophages in polycaprolactone/collagen fibers for antibacterial hemostatic dual-function. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 106(7), 2588-2595. https://doi.org/10.1002/jbm.b.34075

Nielsen, K. H. (2018). Infinitesimal. Weekendavisen, Sektion 4 (Ideer), 10.

Nielsen, K. H. (2018). Information. Weekendavisen, Sektion 4 (Ideer), 10.

Zhu, C., Taipaleenmäki, E. M., Zhang, Y., Han, X. & Stadler, B. M. (2018). Interaction of cells with patterned reactors. Biomaterials Science, 6(4), 793-802. https://doi.org/10.1039/C7BM00838D

Nielsen, K. H. (2018). Internettet. Weekendavisen, Sektion 4 (Ideer), 10.

Nielsen, K. H. (2018). Internettet blev opfundet i en verden præget af den kolde krig. Videnskab.dk.

Jiang, Z., Zhang, S., Klausen, L. H., Song, J., Li, Q., Wang, Z., Stokke, B. T., Huang, Y., Besenbacher, F., Nielsen, L. P. & Dong, M. (2018). In vitro single-cell dissection revealing the interior structure of cable bacteria. Proceedings of the National Academy of Sciences (PNAS), 115(34), 8517-8522. https://doi.org/10.1073/pnas.1807562115

Nielsen, K. H. (2018). Jul. Weekendavisen, Sektion 4 (Ideer), 10.

Nielsen, K. H. (2018). Kampen om naturvidenskabens sjæl: en forvekslingskomedie. Science Report. http://sciencereport.dk/debat/kampen-naturvidenskabens-sjael-forvekslingskomedie/

Nielsen, K. H. & Skydsgaard, M. A. (2018). Konkurrence: Den, der står først. In M. A. Skydsgaard & K. H. Nielsen (Eds.), Videnskab er lidenskab: Med forskere på arbejde (pp. 107-125). Aarhus Universitetsforlag.

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