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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Chen, M., Andersen, M. Ø., Dillschneider, P., Chang, C.-C., Gao, S., Le, D. Q. S., Yang, C., Hein, S., Bünger, C. & Kjems, J. (2015). Co-delivery of siRNA and doxorubicin to cancer cells from additively manufactured implants. RSC Advances, 5, 101718-101725. https://doi.org/10.1039/C5RA23748C

Coudrillier, B., Pijanka, J., Jefferys, J., Sorensen, T., Quigley, H. A., Boote, C. & Nguyen, T. D. (2015). Collagen structure and mechanical properties of the human sclera: analysis for the effects of age. Journal of Biomechanical Engineering, 137(4), 041006. https://doi.org/10.1115/1.4029430

Hansen, T. B., Venø, M. T., Damgaard, C. K. & Kjems, J. (2015). Comparison of circular RNA prediction tools. Nucleic Acids Research. https://doi.org/10.1093/nar/gkv1458

Nielsen, K. H. (2015). Computer. Weekendavisen, Ideer, 10.

Selnihhin, D. & Andersen, E. S. (2015). Computer-aided design of DNA origami structures. In M. A. Marchisio (Ed.), Computational Methods in Synthetic Biology (pp. 23-44). Humana Press.

M. Zadegan, R., Jepsen, M. D. E., Hildebrandt, L., Birkedal, V. & Kjems, J. (2015). Construction of a fuzzy and all Boolean logic gates based on DNA. Small, 11(15), 1811-1817. https://doi.org/10.1002/smll.201402755

Paslawski, W., Lillelund, O. K., Kristensen, J. V., Schafer, N. P., Baker, R. P., Urban, S. & Otzen, D. E. (2015). Cooperative folding of a polytopic α-helical membrane protein involves a compact N-terminal nucleus and nonnative loops. Proceedings of the National Academy of Sciences (PNAS), 112(6), 7978-7983. https://doi.org/10.1073/pnas.1424751112

Halkoaho, A., Pietila, AM., Ebbesen, M., Karki, S. & Kangasnniemi, M. (2015). Cultural aspects related to informed consent in health care research: A systematic review. Nursing Ethics, 1-14. https://doi.org/10.1177/0969733015579312

Zhang, P., Hou, X., Li, S., Liu, D. & Dong, MD. (2015). Curvature effect of O₂ adsorption and dissociation on SiC nanotubes and nanosheet. Chemical Physics Letters, 619, 92-96. https://doi.org/10.1016/j.cplett.2014.11.057

Xiang, F., Lu, Y., Li, C., Song, X., Liu, X., Wang, Z., Liu, J. & Dong, M. (2015). Cyclotrimerization-Induced Chiral Supramolecular Structures of 4-Ethynyltriphenylamine on Au(111) Surface. Chemistry: A European Journal, 21(37), 12978-12983. https://doi.org/10.1002/chem.201501434

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Kalinka Hansen