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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Knudsen, A. D., Bennike, T., Kjeldal, H., Birkelund, S., Otzen, D. & Stensballe, A. (2014). Condenser: A statistical aggregation tool for multi-sample quantitative proteomic data from Matrix Science Mascot Distiller™. Journal of Proteomics, 103, 261-266. https://doi.org/10.1016/j.jprot.2014.02.001

Guo, Z., Panpipat, W., Xia, D., Keskin, H., Dong, MD. & Xu, X. (2014). Condensing Effects of β-sitosteryl Aliphatic Esters on Dipalmitoyl Phosphatidylcholine (DPPC) Monolayers: A structure activity relationship study. In 12th Euro Fed Lipid Congress Book of Abstracts: Oils, Fats and Lipids: From Lipidomics to Industrial Innovation https://gdch.enterprise-ems.de/tms/frontend/index.cfm?l=4569&id=0&dat_h=&sp_id=2&modus=

Rigau, L. H., York Durán, M. J., Zhang, Y., Goldie, K. & Stadler, B. M. (2014). Confined Multiple Enzymatic (Cascade) Reactions within Poly(dopamine)-based Capsosomes. A C S Applied Materials and Interfaces, 6(15), 12771–12779. https://doi.org/10.1021/am502743z

Zhang, P., Hou, X. L., Mi, J. L., Jiang, Q., Aslan, H. & Dong, MD. (2014). Curvature effect of SiC nanotubes and sheets for CO₂ capture and reduction. R S C Advances, 4(90), 48994-48999. https://doi.org/10.1039/c4ra07542k

Andersen, K. K. & Otzen, D. (2014). Denaturation of α-lactalbumin and myoglobin by the anionic biosurfactant rhamnolipid. Biochimica et biophysica acta. Bioenergeticss, 1844(12), 2338-2345. https://doi.org/10.1016/j.bbapap.2014.10.005

Zou, Z., Temkiv, T. S., Jakobsson, J., Benneke, B., Grundahl, F., Kjeldsen, H., Finster, K. & Löndahl, J. (2014). Detection of airborne bacteria with UV-Vis-NIR spectroscopy. Poster session presented at NOSA, Stockholm, Sweden.

Femenias, M. R., Li, Y., Dehli, J., Taskin, M. B., Besenbacher, F. & Chen, M. (2014). Dexamethasone encapsulated coaxial electrospun PCL/PEO hollow microfibers for inflammation regulation. R S C Advances, 4(93), 51537-51543. https://doi.org/10.1039/C4RA08358J

Schiølin, K. (2014). Digitaliseringen af daginstitutionerne: Hvorfor ikke bare lade være? Dansk Pædagogisk Tidsskrift, (3), 6-17.

Kock, A., Zuwala, K., Smith, A. A. A., Ruiz-Sanchis, P., Wohl, B. M., Tolstrup, M. & Zelikin, A. N. (2014). Disulfide reshuffling triggers the release of a thiol-free anti-HIV agent to make up fast-acting, potent macromolecular prodrugs. Chemical Communications, 50(93), 14498-500. https://doi.org/10.1039/c4cc04280h

Ke, Y., Ong, L. L., Sun, W., Song, J., Dong, MD., Shih, W. M. & Yin, P. (2014). DNA brick crystals with prescribed depths. Nature Chemistry, 6(11), 994-1002. https://doi.org/10.1038/nchem.2083

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Kalinka Hansen