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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Nielsen, K. H. & Sørensen, M. P. (2017). How to take non-knowledge seriously, or “the unexpected virtue of ignorance”. Public Understanding of Science, 23(3), 385–392. https://doi.org/10.1177/0963662515600967

Wakelam, V., Bron, E., Cazaux, S., Dulieu, F., Gry, C., Guillard, P., Habart, E., Hornekær, L., Morisset, S., Nyman, G., Pirronello, V., Price, S. D., Valdivia, V., Vidali, G. & Watanabe, N. (2017). H₂ formation on interstellar dust grains: The viewpoints of theory, experiments, models and observations. Molecular Astrophysics, 9, 1-36. https://doi.org/10.1016/j.molap.2017.11.001

Andersen, K. K., Vad, B. S., Scavenius, C., Enghild, J. J. & Otzen, D. E. (2017). Human lysozyme peptidase resistance is perturbed by the anionic glycolipid biosurfactant rhamnolipid produced by the opportunistic pathogen Pseudomonas aeruginosa. Biochemistry, 56(1), 260–270. https://doi.org/10.1021/acs.biochem.6b01009

Nielsen, K. H. (2017). Hvad pokker skal man vælge? Jyllands-Posten, Sektion 6 (U-Days), 4.

Nielsen, K. H. (2017, Oct 6). Hvad sker der, når forskningsresultater ikke kan reproduceres? http://sciencereport.dk/debat/krisestemning-forskningsresultater-ikke-kan-reproduceres/

Hansen, I., Ebbesen, M. F., Kaspersen, L., Thomsen, T. B., Bienk, K., Cai, Y., Malle, B. M. & Howard, K. (2017). Hyaluronic Acid Molecular Weight-Dependent Modulation of Mucin Nanostructure for Potential Mucosal Therapeutic Applications. Molecular Pharmaceutics, 14(7), 2359–2367. https://doi.org/10.1021/acs.molpharmaceut.7b00236

Schiølin, K. (2017). I bisværmen: teknologien i Ernst Jüngers sene fiktionsprosa . In A. Paulsen & A. E. Dam (Eds.), Soldat, arbejder, anark: Ernst Jüngers forfatterskab (pp. 329-358). Museum Tusculanum.

Jeppesen, M. H., Nielsen, C. F., Eriksen, C. B. & Jørgensen, E. K. (Eds.) (2017). Immanuel Kant: Oplysning, historie, fremskridt: Historiefilosofiske skrifter. (2 ed.) Forlaget Slagmark.

Sahyoun, M., Korsholm , U., Sørensen, J., Santl-Temkiv, T., Finster, K., Gosewinkel, U. B. & Nielsen, N. (2017). Impact of bacterial ice nucleating particles on weather predicted by a numerical weather prediction model. Atmospheric Environment, 170(170), 33-44. https://doi.org/10.1016/j.atmosenv.2017.09.029

Yang, C., Gao, S., Dagnæs-Hansen, F., Jakobsen, M. & Kjems, J. (2017). Impact of PEG Chain Length on the Physical Properties and Bioactivity of PEGylated Chitosan/siRNA Nanoparticles in Vitro and in Vivo. A C S Applied Materials and Interfaces, 9(14), 12203-12216. https://doi.org/10.1021/acsami.6b16556

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