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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Hein, K. L., Kragh-Hansen, U., Morth, J. P., Jeppesen, M., Otzen, D., Møller, J. V. & Nissen, P. (2010). Crystallographic analysis reveals a unique lidocaine binding site on human serum albumin. Journal of Structural Biology, 171, 353-360.

Pedersen, M. B., Zhou, X., Larsen, E. K. U., Sørensen, U. S., Kjems, J., Nygaard, J. V., Nyengaard, J. R., Meyer, R. L., Boesen, T. & Vorup-Jensen, T. (2010). Curvature of Synthetic and Natural Surfaces is an Important Target Feature in Classical Pathway Complement Activation. Journal of Immunology, 184(4), 1931-1945. https://doi.org/10.4049/jimmunol.0902214

Hjørringgaard, C. U., Vad, B., Nielsen, S. B., Matchkov, V., Vosegaard, T., Nielsen, N. C., Otzen, D. & Skrydstrup, T. (2010). Cyclodextrin scaffolded alamethicin with highly efficient channel-forming properties. Journal of Peptide Science, 16, 148.

Hjørringgaard, C. U., Vad, B. S., Matchkov, V., Nielsen, S. B., Vosegaard, T., Nielsen, N. C., Otzen, D. & Skrydstrup, T. (2010). Cyclodextrin Scaffolded Alamethicin with Highly Efficient Channel-forming Properties. Poster session presented at 31st European Peptide Symposium, 31EPS, Copenhagen, Denmark.

Nielsen, K. H. (2010). Danmark - verdens førende forskningsnation? Videnskab.dk. http://videnskab.dk/content/dk/blogs/bag_om_videnskaben/danmark_%E2%80%93_verdens_forende_forskningsnation

Kristensen, T. G. & Pedersen, C. N. S. (2010). Data Structures for Accelerating Tanimoto Queries on Real Valued Vectors. In V. Moulton & M. Singh (Eds.), Algorithms in Bioinformatics: 10th International Workshop (WABI 2010) (Vol. 6293, pp. 28-39). Springer.

Mollenhauer, J., Stamou, D., Flyvbjerg, A., Wengel, J., Gether, U., Kjems, J., Bjørnholm, T. & Besenbacher, F. (2010). David versus Goliath. Nanomedicine: Nanotechnology, Biology and Medicine, 6(4), 504-9. https://doi.org/10.1016/j.nano.2010.04.002

Montanini, L., Pazzaglia, L., Spessotto, P., Kjems, J., Conti, A., Perris, R., den Boer, M. L. & Benassi, M. S. (2010). Differential approach to define microRNA expression patterns in osteosarcomas. Proceedings of the American Association of Cancer Research, 51.

Seismann, H., Blank, S., Braren, I., Greunke, K., Cifuentes, L., Grunwald, T., Bredehorst, R., Ollert, M. & Spillner, E. (2010). Dissecting cross-reactivity in hymenoptera venom allergy by circumvention of alpha-1,3-core fucosylation. Molecular immunology, 47(4), 799-808. https://doi.org/10.1016/j.molimm.2009.10.005