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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Søndergaard, D. A., Knudsen, M. & Pedersen, C. S. (2016). Computational Classification of P-Type ATPases. Methods in Molecular Biology, 1377, 493-502. https://doi.org/10.1007/978-1-4939-3179-8

Knudsen, M., Søndergaard, D. A., Tofting-Olesen, C., Hansen, F. T., Brodersen, D. E. & Pedersen, C. S. (2016). Computational discovery of specificity-conferring sites in non-ribosomal peptide synthetases. Bioinformatics, 32(3), 325-329. https://doi.org/10.1093/bioinformatics/btv600

Andersen, K. K., Vad, B., Omer, S. & Otzen, D. E. (2016). Concatemers of Outer Membrane Protein A Take Detours in the Folding Landscape. Biochemistry, 55(51), 7123–7140. https://doi.org/10.1021/acs.biochem.6b01153

Yang, X., Li, Q., Hu, G., Wang, Z., Yang, Z., Liu, X., Dong, M. & Pan, C. (2016). Controlled synthesis of high-quality crystals of monolayer MoS2 for nanoelectronic device application. Science china-Materials, 59(3), 182-190. https://doi.org/10.1007/s40843-016-0130-1

Song, X., Wang, Z., Liu, X., Dong, M. & Wang, L. (2016). Controlling the intracell diffusion behaviour of Ag monomers on Si(111)-(7 x 7) by voltage pulse manipulation. Applied Physics Letters, 109(10), 177-180. Article 103105. https://doi.org/10.1063/1.4962497

Westberg, M., Bregnhøj, M., Blazquez-Castro, A., Breitenbach, T., Etzerodt, M. & Ogilby, P. R. (2016). Control of Singlet Oxygen Production in Experiments Performed on Single Mammalian Cells. Journal of Photochemistry and Photobiology, A: Chemistry, 321, 297-308. https://doi.org/10.1016/j.jphotochem.2016.01.028

Nielsen, K. H. (2016). CRISPR. Weekendavisen, Ideer, 10.

Schiølin, K. H. (2016). Cum Deus Calculat, Fit Mundus, or The Will to Technology: Diagnosis and Cure. A Peer-Reviewed Journal About, 5(1). http://www.aprja.net/?p=3083

Bortolini, C. & Dong, M. (2016). Cystine oligomers successfully attached to peptide cysteine-rich fibrils. Frontiers of Chemical Science and Engineering, 10(1), 99-102. https://doi.org/10.1007/s11705-016-1554-6

Hall, J. P., Keane, P. M., Beer, H., Buchner, K., Winter, G., Sorensen, T. L., Cardin, D. J., Brazier, J. A. & Cardin, C. J. (2016). Delta chirality ruthenium 'light-switch' complexes can bind in the minor groove of DNA with five different binding modes. Nucleic Acids Research, 44(19), 9472-9482. https://doi.org/10.1093/nar/gkw753

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Kalinka Hansen