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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Finster, K. (2011). Desulfocapsa sp., sulfur disproportionators as a model of a chemolithoautotrophic "LUCA".. Abstract from ISSM 2011 8th International Symposium of Subsurface Microbiology, Garmisch-Partenkirchen, Germany.

Xu, S., Yang, Y., Xu, T., Kuang, Y., Dong, M., Zhang, F., Besenbacher, F. & Evans, D. G. (2011). Engineered morphologies of layered double hydroxide nanoarchitectured shell microspheres and their calcined products. Chemical Engineering Science, 66(10). https://doi.org/10.1016/j.ces.2011.02.024

Hansen, T. B., Kjems, J. & Bramsen, J. B. (2011). Enhancing miRNA annotation confidence in miRBase by continuous cross dataset analysis. RNA Biology, 8(3), 378-383.

Mailund, T., Dutheil, J., Hobolth, A., Lunter, G. & Schierup, M. H. (2011). Estimating Divergence Time and Ancestral Effective Population Size of Bornean and Sumatran Orangutan Subspecies Using a Coalescent Hidden Markov Model. PLoS Genetics, 7(3). https://doi.org/10.1371/journal.pgen.1001319

Caden-Nava, R. D., Hu, Y., Garmann, R. F., Ng, B., Zelikin, A. N., Knobler, C. M. & Gelbart, W. M. (2011). Exploiting Fluorescent Polymers To Probe the Self-Assembly of Virus-like Particles. Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical, 115, 2386-2391. https://doi.org/10.1021/jp1094118

Kristensen, J. L. H. & Nielsen, K. H. (2011). Exploring Socio-Linguistic Contexts of Children's Learning About Great Ape Conservation in a Zoo. IZE Journal, (47), 10-14.

Nielsen, K. H. (2011). Exploring the Dialogic Space of Public Participation in Science. Abstract from 4S Annual Meeting, Cleveland, OH, United States. http://www.4sonline.org/files/Print_Program_Abstracts_final.pdf

Dueholm, M. S., Nielsen, S. B., Hein, K. L., Nissen, P., Chapman, M., Christiansen, G., Nielsen, P. H. & Otzen, D. E. (2011). Fibrillation of the major curli subunit CsgA under a wide range of conditions implies a robust design of aggregation. Biochemistry, 50(39), 8281-90. https://doi.org/10.1021/bi200967c

Andersen, E. S. (2011). Fremtidens bio-nanoteknologi – design dine egne molekyler. In P. K. Gasbjerg, G. S. Jensen & A. B. Sørensen (Eds.), Bioteknologi – en temabog (pp. 159-168). Systime.