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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Nielsen, K. H. (2015). Philosophy of citizen science in practice. Abstract from Fifth Biennial Conference of the Society for Philosophy of Science in Practice, Aarhus, Denmark.

Vad, B. S., Balakrishnan, V. S., Nielsen, S. B. & Otzen, D. (2015). Phospholipid Ether Linkages Significantly Modulate the Membrane Affinity of the Antimicrobial Peptide Novicidin. Journal of Membrane Biology, 487-496. https://doi.org/10.1007/s00232-015-9792-y

Panneerselvam, K., Lynge, M. E., Riber, C. F., Mena-Hernando, S., Smith, A. A. A., Goldie, K. N., Zelikin, A. N. & Stadler, B. (2015). Phospholipid-polymer amphiphile hybrid assemblies and their interaction with macrophages. Biomicrofluidics, 9(5), Article 052610. https://doi.org/10.1063/1.4929405

Froning, J. P., Xia, D., Zhang, S., Laegsgaard, E., Besenbacher, F. & Dong, M. (2015). Piezoelectric oscillation sensor based noncontact atomic force microscope for imaging in both ambient and liquid environments. Journal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures, 33(2), Article 021801. https://doi.org/10.1116/1.4906517

Nielsen, K. H. (2015). Plast. In H. Kragh & K. H. Nielsen (Eds.), 50 opfindelser: Højdepunkter i teknologien (pp. 171-175). Aarhus Universitetsforlag.