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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Koefoed, L., Kongsfelt, M., Ulstrup, S., Cabo, A. G., Cassidy, A., Whelan, P. R., Bianchi, M., Dendzik, M., Pizzocchero, F., Jørgensen, B., Bøggild, P., Hornekær, L., Hofmann, P., Pedersen, S. U. & Daasbjerg, K. (2015). Facile electrochemical transfer of large-area single crystal epitaxial graphene from Ir(111). Journal of Physics D: Applied Physics, 48(11), Article 115306. https://doi.org/10.1088/0022-3727/48/11/115306

Feng, H., Wu, C., Zhang, P., Mi, J. & Dong, M. (2015). Facile hydrothermal synthesis and formation mechanisms of Bi₂Te₃, Sb₂Te₃ and Bi₂Te₃-Sb₂Te₃ nanowires. RSC Advances, 5(121), 100309-100315. https://doi.org/10.1039/c5ra20014h

Jiang, Z., Wang, M., Cheng, H., Li, J., Aslan, H., Lv, H., Yao, Y., Shao, L., Huang, Y. & Dong, M. (2015). Facile Preparation of TiO2 Nanoclusters on Graphene Templates for Photodegradation of Organic Compounds. Journal of Materials Science & Technology, 31(8), 840-844. https://doi.org/10.1016/j.jmst.2015.01.011

Hirsch, C., Neuhäuser, D., Gloaguen, C. & Schmidt, V. (2015). First passage percolation on random geometric graphs and an application to shortest-path trees. Advances in Applied Probability, 47(2), 328-354.

Nielsen, H., Nielsen, K. H., Nielsen, K. & Jensen, H. S. (2015). Forandringens vinde: Nye teknologihistorier. Praxis - Nyt Teknisk Forlag.

Nielsen, K. H. (2015). Forandringens vinde. Videnskab.dk [online]. http://videnskab.dk/blog/forandringens-vinde

Nielsen, K. H. & Busch, J. (2015). Forskningsfriheden flyver. Aktuel Naturvidenskab, (5), 5.

Sukosd, Z., Andersen, E. S., Seemann, S. E., Jensen, M., Hansen, M. B., Gorodkin, J. & Kjems, J. (2015). Full-length RNA structure prediction of the HIV-1 genome reveals a conserved core domain. Nucleic Acids Research, 43(21), 10168-10179. https://doi.org/10.1093/nar/gkv1039

Seviour, T., Hansen, S. H., Yang, L., Yau, Y. H., Wang, V. B., Stenvang, M. R., Christiansen, G., Marsili, E., Givskov, M., Chen, Y., Otzen, D., Nielsen, P. H., Shochat, S. G., Kjelleberg, S. & Dueholm, M. S. (2015). Functional Amyloids Keep Quorum Sensing Molecules in Check. Journal of Biological Chemistry, 290, 6457-6469. https://doi.org/10.1074/jbc.M114.613810