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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Pedersen, J. S. & Otzen, D. (2008). Amyloid - a state in many guises: survival of the fittest fibril fold. Protein Science, 17, 1-9.

Larsen, P., Nielsen, J. L. & Otzen, D. (2008). Amyloid-like adhesins in floc-forming and filamentous bacteria in activated sludge. Applied and Environmental Microbiology, 74, 1517-1526.

Finster, K. (2008). Anaerobic bacteria and archaea in cold ecosystems. In Psychrophiles: From Biodiversity to Biotechnology (pp. 103-119). Springer. https://doi.org/10.1007/978-3-540-74335-4_7

Nielsen, K. H. & Ebbesen, M. (2008). Analyse: Etik. Er nanoteknologi et tveægget sværd? Politiken, 8.

Dupont, D. M., Kjems, J., Andreasen, P. & Madsen, J. C. B. (2008). A new way of targeting protease-receptor binding: Selection of uPA binding RNA aptamers inhibiting its association to its receptor uPAR. Acta Pathologica Microbiologica et Immunologica Scandinavica, 443-443.

Haaning, S., Radutoiu, S., Hoffmann, S. V., Dittmer, J., Giehm, L., Otzen, D. & Stougaard, J. (2008). An unusual intrinsically disordered protein from the model legume Lotus japonicus stabilizes proteins in vitro. Journal of Biological Chemistry, 283(45), 31142-52. https://doi.org/10.1074/jbc.M805024200

Ebbesen, M. (2008). Beneficence: . In Encyclopedia of Medical Decision Making: SAGE Publications.

Nielsen, H. & Nielsen, K. H. (2008). Boundless knowledge, 1920-1970. In H. Kragh, P. C. Kjærgaard, H. Nielsen & K. H. Nielsen (Eds.), Science in Denmark: A Thousand-Year History (pp. 385-550). Aarhus Universitetsforlag.

Rauls, E. & Hornekær, L. (2008). Catalyzed routes to molecular hydrogen formation and hydrogen addition reactions on neutral polycyclic aromatic hydrocarbons under interstellar conditions. Astrophysical Journal, 679, 531-536.

Nielsen, K. H. (2008). Challenging hyperprofessionalisation vs. hyperpopularisation in the history of science. Abstract from Challenging hyperprofessionalism: The intradisciplinarity of science, technology, medicine and climate studies, Århus, Denmark. http://www.stm.au.dk/octconference/abstracts

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