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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Yang, Q., Dong, L., Su, R., Hu, B., Wang, Z., Jin, Y., Wang, Y., Besenbacher, F. & Dong, M. (2019). Nanostructured heterogeneous photo-catalysts for hydrogen production and water splitting: A comprehensive insight. Applied Materials Today, 17, 159-182. https://doi.org/10.1016/j.apmt.2019.07.016

Nielsen, K. H. (2019). Naturkatastrofe. Weekendavisen, Sektion 4 (Ideer), 10.

Juul, M., Madsen, T., Guo, Q., Bertl, J., Hobolth, A., Kellis, M. & Pedersen, J. S. (2019). ncdDetect2: Improved models of the site-specific mutation rate in cancer and driver detection with robust significance evaluation. Bioinformatics, 35(2), 189-199. https://doi.org/10.1093/bioinformatics/bty511

Knudsen, L. J., Nielsen, S. D.-H., Rauh, V., Otzen, D. & Larsen, L. B. (2019). New Lactase Enzymes. Abstract from Sandbjerg Seminar 2019, Sønderborg, Denmark.

Frich, C. K., Krüger, F., Walther, R., Domar, C., Andersen, A. H. F., Tvilum, A., Dagnæs-Hansen, F., Denton, P. W., Tolstrup, M., Paludan, S. R., Münch, JJ. & Zelikin, A. N. (2019). Non-covalent hitchhiking on endogenous carriers as a protraction mechanism for antiviral macromolecular prodrugs. Journal of Controlled Release, 294, 298-310. https://doi.org/10.1016/j.jconrel.2018.12.016

Krüger, F., Kumar, V., Monge, P., Conzelmann, C., Smith, N., Gothelf, K. V., Tolstrup, M., Münch, J. & Zelikin, A. N. (2019). Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues. Advanced Science, 6(6), Article 1802095. https://doi.org/10.1002/advs.201802095

Nielsen, K. H. (2019). Økologi. Weekendavisen, Sektion 4 (Ideer), 10.

Mohammad-Beigi, H., Aliakbari, F., Sahin, C., Lomax, C., Tawfike, A., P. Schafer, N., Amiri-Nowdijeh, A., Eskandari, H., Møller, I. M., Hosseini-Mazinani, M., Christiansen, G., Ward, J. L., Morshedi, D. & Otzen, D. (2019). Oleuropein derivatives from olive fruit extracts reduce α-synuclein fibrillation and oligomer toxicity. Journal of Biological Chemistry, 294(11), 4215-4232. https://doi.org/10.1074/jbc.RA118.005723

Basse-O'Connor, A., Heinrich, C. & Podolskij, M. (2019). On limit theory for functionals of stationary increments Lévy driven moving averages. Electronic Journal of Probability, 24, Article 79. https://doi.org/10.1214/19-EJP336

Hall, A., Nicholls , K., Caspersen , M. B., Skrivergaard, S., Howard, K., Karu, K., Chudasama, V. & Baker, J. R. (2019). Optimised approach to albumin-drug conjugates using monobromomaleimide-C-2 linkers. Organic & Biomolecular Chemistry, 17(34), 7870-7873. https://doi.org/10.1039/C9OB00721K

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Kalinka Hansen