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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Nielsen, K. H. (2016). Acceleration. Weekendavisen, Ideer, 10.

Christensen, L. F. B., Malmos, K. G., Christiansen, G. & Otzen, D. E. (2016). A Complex Dance: The Importance of Glycosaminoglycans and Zinc in the Aggregation of Human Prolactin. Biochemistry, 55(26), 3674–3684. https://doi.org/10.1021/acs.biochem.6b00153

Lobley, C. M. C., Sandy, J., Sanchez-Weatherby, J., Mazzorana, M., Krojer, T., Nowak, R. P. & Sorensen, T. L. (2016). A generic protocol for protein crystal dehydration using the HC1b humidity controller. Acta crystallographica Section D: Structural biology, 72(Pt 5), 629-640. https://doi.org/10.1107/S2059798316003065

Larsen, M. T., Kuhlmann, M., Hvam, M. L. & Howard, K. (2016). Albumin-based drug delivery: harnessing nature to cure disease. Molecular and Cellular Therapies, 4(3), 3. https://doi.org/10.1186/s40591-016-0048-8

Smith, A. A. A., Zuwala, K., Pilgram, O., Johansen, K. S. E., Tolstrup, M., Dagnæs-Hansen, F. & Zelikin, A. N. (2016). Albumin–Polymer–Drug Conjugates: Long Circulating, High Payload Drug Delivery Vehicles. ACS Macro Letters, 5(10), 1089-1094. https://doi.org/10.1021/acsmacrolett.6b00544

Riehl, L., Seyboldt, A., Ströbele, M., Enseling, D., Jüstel, T., Westberg, M., Ogilby, P. R. & Meyer, H. .-J. (2016). A ligand substituted tungsten iodide cluster: luminescence vs. singlet oxygen production. Dalton Transactions, 45(39), 15500-15506. https://doi.org/10.1039/C6DT02471H

Pantusa, M., Vad, B., Lillelund, O., Kjær, L., Otzen, D. & Bartucci, R. (2016). Alpha-synuclein and familial variants affect the chain order and the thermotropic phase behavior of anionic lipid vesicles. Biochimica et Biophysica Acta - Proteins and Proteomics, 1864(9), 1206-1214. https://doi.org/10.1016/j.bbapap.2016.05.003

Tian, P., Lindorff-Larsen, K., Boomsma, W., Jensen, M. H. & Otzen, D. E. (2016). A Monte Carlo Study of the Early Steps of Functional Amyloid Formation. PLoS One, 11(1), Article e0146096. https://doi.org/10.1371/journal.pone.0146096

Bienk, K., Hvam, M. L., Pakula, M. M., Dagnæs-Hansen, F., Wengel, J., Malle, B. M., Kragh-Hansen, U., Cameron, J., Bukrinski, J. T. & Howard, K. (2016). An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing. Journal of Controlled Release, 232, 143-151. https://doi.org/10.1016/j.jconrel.2016.04.013

Nielsen, K. H. (2016). Antropocæn. Weekendavisen, Ideer, 10.

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Kalinka Hansen