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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Martirosyan, A., Olesen, M. J., Fenton, R. A., Kjems, J. & Howard, K. A. (2016). Mucin-mediated nanocarrier disassembly for triggered uptake of oligonucleotides as a delivery strategy for the potential treatment of mucosal tumours. Nanoscale, 8(25), 12599-12607. https://doi.org/10.1039/c5nr07206a

Li, Z., Hu, Y., Howard, K., Yiang, T., Fan, X., Miao, Z., Sun, Y., Besenbacher, F. & Yu, M. (2016). Multifunctional bismuth selenide nanocomposites for anti-tumor thermo-chemotherapy and imaging. A C S Nano, 10(1), 984-997. https://doi.org/10.1021/acsnano.5b06259

Li, Z., Liu, J., Howard, K., Fan, X., Chang, M., Sun, Y., Besenbacher, F. & Yu, M. (2016). Multimodal Imaging-Guided Antitumor Photothermal Therapy and Drug Delivery Using Bismuth Selenide Spherical-Sponge. A C S Nano, 10(10), 9646–9658. https://doi.org/10.1021/acsnano.6b05427

Duan, X., Liu, Z., Gan, Y., Xia, D., Li, Q., Li, Y., Yang, J., Gao, S. & Dong, M. (2016). Mutations in COL1A1 Gene Change Dentin Nanostructure. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 299(4), 511-519. https://doi.org/10.1002/ar.23308

Howard, K. (2016). Nanomedicine: Working towards defining the field. In K. A. Howard, T. Vorup-Jensen & D. Peer (Eds.), Nanomedicine (pp. 1-12). Springer. https://doi.org/10.1007/978-1-4939-3634-2_1

Dong, M., Liu, L. & Zhang, S. (2016). Nanostructural Biomaterials and Applications. Journal of Nanomaterials, 2016, Article 5903201. https://doi.org/10.1155/2016/5903201

Kulminskaya, N. V., Yoshimura, Y., Runager, K., Sørensen, C. S., Bjerring, M., Andreasen, M., Otzen, D. E., Enghild, J. J., Nielsen, N. C. & Mulder, F. A. A. (2016). Near-complete ¹H, ¹³C, ¹⁵N resonance assignments of dimethylsulfoxide-denatured TGFBIp FAS1-4 A546T. Biomolecular N M R Assignments, 10(1), 25-29. https://doi.org/10.1007/s12104-015-9630-2

Petersen, S., Kläning, E., Andersen, B., Cameron, J., Sørensen, E. S. & Howard, K. (2016). Neonatal Fc Receptor Binding Tolerance toward the Covalent Conjugation of Payloads to Cysteine 34 of Human Albumin Variants. Molecular Pharmaceutics, 13(2), 677–682. https://doi.org/10.1021/acs.molpharmaceut.5b00605

Jakobsen, H. J., Song, L., Gan, Z., Hung, I., Bildsoe, H., Skibsted, J., Bak, E. N., Finster, K., Nornberg, P. & Jensen, S. K. (2016). NMR and EPR Studies of Free-Radical Intermediates from Experiments Mimicking the Winds on Mars: A Sink for Methane and Other Gases. The Journal of Physical Chemistry Part C, 120(45), 26138-26149. https://doi.org/10.1021/acs.jpcc.6b08847

Nielsen, K. H. (2016). Nordic Perspectives on STS. Abstract from DASTS 2016, Aarhus, Denmark.

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Kalinka Hansen