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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Schlafer, S., Raarup, M. K., Wejse, P. L., Nyvad, B., Stadler, B. M., Sutherland, D. S., Birkedal, H. & Meyer, R. L. (2012). Osteopontin Reduces Biofilm Formation in a Multi-Species Model of Dental Biofilm. PLoS One, 7(8), e41534. https://doi.org/10.1371/journal.pone.0041534

Nielsen, K. H. (2012). Overdrivelse fremmer forståelsen. Videnskab.dk. http://videnskab.dk/blog/overdrivelse-fremmer-forstaelsen

Larciprete, R., Ulstrup, S., Lacovig, P., Dalmiglio, M., Bianchi, M., Mazzola, F., Hornekær, L., Orlando, F., Baraldi, A., Hofmann, P. & Lizzit, S. (2012). Oxygen Switching of the Epitaxial Graphene-Metal Interaction. A C S Nano, 6(11), 9551–9558. https://doi.org/10.1021/nn302729j

Gonzalez, B. B. & Howard, K. (2012). Polycation-based nanoparticle delivery of RNAi therapeutics: Adverse effects and solutions. Advanced Drug Delivery Reviews, 64(15), 1717-1729. https://doi.org/10.1016/j.addr.2012.07.004

Andreasen, M., Nielsen, S. B., Runager, K., Christiansen, G., Nielsen, N. C., Enghild, J. J. & Otzen, D. (2012). Polymorphic Fibrillation of the Destabilized Fourth Fasciclin-1 Domain Mutant A₅₄6T of the Transforming Growth Factor-β-induced Protein (TGFBIp) Occurs through Multiple Pathways with Different Oligomeric Intermediates. Journal of Biological Chemistry, 287(41), 34730-34742. https://doi.org/10.1074/jbc.M112.379552

Spillner, E., Blank, S. & Jakob, T. (2012). Potenzial, Fallstricke und aktueller Status der molekularen Diagnostik am Beispiel der Insektengiftallergie. Allergo Journal, 21(4), 249-256. https://doi.org/10.1007/s15007-012-0128-2

Pedersen, L. R. L., Nielsen, S. B., Hansted, J. G., Petersen, T. E., Otzen, D. E. & Sørensen, E. S. (2012). PP3 forms stable tetrameric structures through hydrophobic interactions via the C-terminal amphipathic helix and undergoes reversible thermal dissociation and denaturation. FEBS journal, 279(2), 336-47. https://doi.org/10.1111/j.1742-4658.2011.08428.x

Sükösd, Z., Knudsen, B., Kjems, J. & Pedersen, C. N. S. (2012). PPfold 3.0: fast RNA secondary structure prediction using phylogeny and auxiliary data. Bioinformatics, 28(20), 2691-2692. https://doi.org/10.1093/bioinformatics/bts488

Eriksen, C. B. (2012, Oct 17). Prævention og præformation, eller: Kondomer i Oplysningstiden. http://baggrund.com/praevention-og-praeformation-eller-kondomer-i-oplysningstiden/

Nilsson, L., Andersen, M., Bjerre, J., Balog, R., Hammer, B., Hornekær, L. & Stensgaard, I. (2012). Preservation of the Pt(100) surface reconstruction after growth of a continuous layer of graphene. Surface Science, 606(3-4), 464–469. https://doi.org/10.1016/j.susc.2011.11.007

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Kalinka Hansen