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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Schiølin, K. H. & Riis, S. (2013). Indledning. In K. Schiølin & S. Riis (Eds.), Nye spørgsmål om teknikken (pp. 13-28). Aarhus Universitetsforlag.

Lorenzen, N., E. Wanker, E. & Otzen, D. (2013). Inhibitors of amyloid and oligomer formation. In D. E. Otzen (Ed.), Amyloid Fibrils and Prefibrillar Aggregates: Molecular and Biological Properties (pp. 345-372). Wiley-VCH. https://doi.org/10.1002/9783527654185

Thrower, J. D., Friis, E. E., Skov, A. L., Nilsson, L., Andersen, M., Ferrighi, L., Jørgensen, B., Baouche, S., Balog, R., Hammer, B. & Hornekær, L. (2013). Interaction between coronene and graphite from temperature-programmed desorption and DFT-vdW calculations: Importance of entropic effects and insights into graphite interlayer binding. The Journal of Physical Chemistry Part C, 117(26), 13520-13529. https://doi.org/10.1021/jp404240h

Song, J., Zhang, Z., Zhang, S., Liu, L., Li, Q., Xie, E., Gothelf, K. V., Besenbacher, F. & Dong, M. (2013). Isothermal Hybridization Kinetics of DNA Assembly of Two-Dimensional DNA Origami. Small, 9(17). https://doi.org/10.1002/smll.201202861

Ostenfeld, M. S., Jeppesen, D. K., Laurberg, J. R., Boysen, A., Howard, K., Christensen, E. I., Morth, P., Bui, K. H., Theodorescu, D., Jensen, J. B., Borre, M., Dyrskjøt, L. & Ørntoft, T. F. (2013). Keystone Symposia "ncRNAs in Development and Cancer", Vancouver, Canada: Increased release of exosomes and export of invasion-modulating miRNAs miR921, -23b, -and -224 from metastatic urothelial carcinoma cells.

Nielsen, K. H. (2013). Klimaforandringer som marked og dramatik. Videnskab.dk. http://videnskab.dk/blog/klimaforandringer-som-marked-og-dramatik

Nielsen, K. H. (2013). Klima-slaveri. Aktuel Naturvidenskab, (2), 46-48. http://aktuelnaturvidenskab.dk/fileadmin/Aktuel_Naturvidenskab/nr-2/AN_2_2013slaveri.pdf

Nielsen, K. H. (2013). Kritik af Sciences uvidenskabelige fupnummer. Videnskab.dk. http://videnskab.dk/blog/kritik-af-sciences-uvidenskabelige-fupnummer

Nielsen, K. H. (2013). Kritisk videnskabsjournalistik. Videnskab.dk. http://videnskab.dk/blog/kritisk-videnskabs-journalistik

Jensen, B. E. B., Rigau, L. H., Spycher, P., Reimhult, E., Stadler, B. M. & Zelikin, A. N. (2013). Lipogels: Surface-Adherent Composite Hydrogels Assembled from Poly(Vinyl Alcohol) and Liposomes. Nanoscale, 5(15), 6758-6766. https://doi.org/10.1039/c3nr01662e

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Kalinka Hansen