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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Zelikin, A. N., Ehrhardt, C. & Healy, A. M. (2016). Materials and methods for delivery of biological drugs. Nature Chemistry, 8(11), 997-1007. https://doi.org/10.1038/nchem.2629

Nielsen, K. H. (2016). Meter. Weekendavisen, Ideer, 10.

Bak, E. N., Jensen, S. K., Nørnberg, P. & Finster, K. (2016). Methylated silicates may explain the release of chlorinated methane from Martian soil. Earth and Planetary Science Letters, 433, 226-231. https://doi.org/10.1016/j.epsl.2015.10.044

Kristoffersen, E. L., Jepsen, M. L., Knudsen, B. R. & Ho, Y.-P. (2016). Microfluidics-based Single Cell Analytical Platforms for Characterization of Cancer. In A. K. Howard, T. Vorup-Jensen & D. Peer (Eds.), Nanomedicine (pp. 77-95). Springer. https://doi.org/10.1007/978-1-4939-3634-2_5

Svenningsen, K., Venø, M. T., Henningsen, K., Mallien, A. S., Jensen, L., Christensen, T., Kjems, J., Vollmayr, B. & Wiborg, O. (2016). MicroRNA Profiling in the Medial and Lateral Habenula of Rats Exposed to the Learned Helplessness Paradigm: Candidate Biomarkers for Susceptibility and Resilience to Inescapable Shock. PLoS One, 11(8), Article e0160318. https://doi.org/10.1371/journal.pone.0160318

Henshall, D. C., Hamer, H. M., Pasterkamp, R. J., Goldstein, D. B., Kjems, J., Prehn, J. H. M., Schorge, S., Lamottke, K. & Rosenow, F. (2016). MicroRNAs in epilepsy: pathophysiology and clinical utility. Lancet Neurology, 15(13), 1368-1376. https://doi.org/10.1016/S1474-4422(16)30246-0

Hirsch, C., Neuhäuser, D. & Schmidt, V. (2016). Moderate deviations for shortest-path lengths on random segment processes. ESAIM - Probability and Statistics, 20, 261-292.

Wang, Z., Chen, Y., Li, P., Zhou, J., He, J., Zhang, W., Guo, Z., Li, Y. & Dong, M. (2016). Modulation of N-bonding configurations and their influence on the electrical properties of nitrogen-doped graphene. RSC Advances, 6(95), 92682-92687. https://doi.org/10.1039/c6ra19278e