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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Eriksen, C. B. (2017). Circulation of Blood and Money in Leviathan - Hobbes on the Economy of the Body. In J. Bek-Thomsen, C. Olaf Christiansen, S. Gaardsmand Jacobsen & M. Thorup (Eds.), Ethical Economy: Economic Reasoning as Knowledge and Practice Authority (pp. 31-41). Springer. https://doi.org/10.1007/978-3-319-52815-1_4

Nielsen, K. H. (2017). Cod Society: The Technopolitics of Modern Greenland. In L.-A. Körber, S. MacKenzie & A. W. Stenport (Eds.), Arctic Environmental Modernities: From the Age of Polar Exploration to the Era of the Anthropocene (1 ed., pp. 71-85). Palgrave Macmillan.

Jakob, T. & Spillner, E. (2017). Comparing sensitivity of Hymenoptera allergen components on different diagnostic assay systems: Comparing apples and oranges. Journal of Allergy and Clinical Immunology, 139(3), 1066-1067. https://doi.org/10.1016/j.jaci.2016.09.058

Domljanovic, I., Carstens, A., Okholm, A., Kjems, J., Nielsen, C. T., Heegaard, N. H. H. & Astakhova, K. (2017). Complexes of DNA with fluorescent dyes are effective reagents for detection of autoimmune antibodies. Scientific Reports, 7(1), Article 1925. https://doi.org/10.1038/s41598-017-02214-0

Jakob, T., Müller, U., Helbling, A. & Spillner, E. (2017). Component resolved diagnostics for Hymenoptera venom allergy. Current Opinion in Allergy and Clinical Immunology, 17(5), 363-372. https://doi.org/10.1097/ACI.0000000000000390

Sparvath, S. L., Geary, C. W. & Andersen, E. S. (2017). Computer-aided design of RNA origami structures. Methods in Molecular Biology, 1500, 51-80. https://doi.org/10.1007/978-1-4939-6454-3_5