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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Skivesen, N., Tetu, A., Kristensen, M., Kjems, J., Frandsen, L. H. & Borel, P. I. (2007). Planar photonic crystal waveguide biosensor. Poster session presented at ECIO, København, Denmark.

Howard, K. A. & Kjems, J. (2007). Polycation-based nanoparticle delivery for improved RNA interference therapeutics. Expert opinion on biological therapy, 7(12), 1811-1822. https://doi.org/10.1517/14712598.7.12.1811

Howard, K. A. & Kjems, J. (2007). Polycation-based nanoparticle delivery for improved RNAi therapeutics. Expert Opin. Biol. Ther, 7, 1811-1822.

Kölln, J., Braren, I., Bredehorst, R. & Spillner, E. (2007). Purification of native and recombinant cobra venom factor using thiophilic adsorption chromatography. Protein and Peptide Letters, 14(5), 475-80.

Hovgaard, M. B., Dong, M., Otzen, D. E. & Besenbacher, F. (2007). Quartz crystal microbalance studies of multilayer glucagon fibrillation at the solid-liquid interface. Biophysical Journal, 93(6), 2162-9. https://doi.org/10.1529/biophysj.107.109686

Hovgaard, M. B., Dong, M., Otzen, D. & Besenbacher, F. (2007). Quartz crystal microbalance studies of multilayer glucagons fibrillation at the solid-liquid interface. Biophysical Journal, 93(6), 2162.

Chen, M., Maetzke, A., Jensen, S. K. & Gothelf, K. V. (2007). Rearrangement of S-2-Aminoethyl Phosphorothioates to N-2-Mercaptoethylphosphoramidates and Application for Labeling of DNA. European Journal of Organic Chemistry, 35, 5826-5833.

Chen, M., Jensen, S. K. & Gothelf, K. V. (2007). Rearrangement of S-(2-aminoethyl) thiophosphates to N-(2-mercaptoethyl)- phosphoramidates. European Journal of Organic Chemistry, 2007(35), 5826-5833. https://doi.org/10.1002/ejoc.200700646

Nielsen, K. H., Kjaer, C. R. & Dahlgaard, J. (2007). Scientists and science communication: A Danish survey. Journal of Science Communication, 6(1).

Nielsen, K. B., Sørensen, S., Cartegni, L., Corydon, T. J., Doktor, T. K., Schroeder, L. D., Reinert, L. S., Elpeleg, O., Krainer, A. R., Gregersen, N., Kjems, J. & Andresen, B. S. (2007). Seemingly neutral polymorphic variants may confer immunity to splicing-inactivating mutations: a synonymous SNP in exon 5 of MCAD protects from deleterious mutations in a flanking exonic splicing enhancer. American Journal of Human Genetics, 80(3), 416-432. https://doi.org/10.1086/511992

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Kalinka Hansen