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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Hansen, L. K., Balog, R., Angot, T., Hornekaer, L. & Bisson, R. (2016). Hydrogenated graphene on Ir(111): A high-resolution electron energy loss spectroscopy study of the vibrational spectrum. Physical Review B, 93(11), Article 115403. https://doi.org/10.1103/PhysRevB.93.115403

Jakob, T., Spillner, E. & Lamers, M. (2016). IgE als Zielstruktur für therapeutische Intervention. In T. Biedermann, H. Renz, W. Heppt & M. Röcken (Eds.), Allergologie (pp. 631-640). Springer. https://doi.org/10.1007/978-3-642-37203-2_58

Saura-Múzquiz, M., Granados-Miralles, C., Stingaciu, M., Bøjesen, E. D., Li, Q., Song, J., Dong, MD., Eikeland, E. & Christensen, M. (2016). Improved performance of SrFe₁₂O₁₉ bulk magnets through bottom-up nanostructuring. Nanoscale, 8(5), 2857-2866. https://doi.org/10.1039/C5NR07854G

Madsen, J. L. H., Hjørringgaard, C. U., Vad, B. S., Otzen, D. & Skrydstrup, T. (2016). Incorporation of β-Silicon-β3-Amino Acids in the Antimicrobial Peptide Alamethicin Provides a 20-Fold Increase in Membrane Permeabilization. Chemistry: A European Journal, 22(24), 8358-8367. https://doi.org/10.1002/chem.201600445

Song, W., Shi, M., Dong, M. & Zhang, Y. (2016). Inducing Temporal and Reversible Autophagy by Nanotopography for Potential Control of Cell Differentiation. A C S Applied Materials and Interfaces, 8(49), 33475-33483. https://doi.org/10.1021/acsami.6b11699

Nielsen, S., Simonsen, S. & Hobolth, A. (2016). Inferring Population Genetic Parameters: Particle Filtering, HMM, Ripley’s K-Function or Runs of Homozygosity? In M. Frith & C. Nørgaard Storm Pedersen (Eds.), Algorithms in Bioinformatics - 16th International Workshop, WABI 2016, Proceedings (Vol. 9838, pp. 234-245). Springer. https://doi.org/10.1007/978-3-319-43681-4_19

Vinther, M. & Kjems, J. (2016). Interfacing DNA nanodevices with biology: Challenges, solutions and perspectives. New Journal of Physics, 18(8), Article 085005. https://doi.org/10.1088/1367-2630/18/8/085005

Schaffert, D. H., Okholm, A. H., Sørensen, R. S., Nielsen, J., Tørring, T., Rosen, C. B., Kodal, A. L. B., Mortensen, M. R., Gothelf, K. V. & Kjems, J. (2016). Intracellular Delivery of a Planar DNA Origami Structure by the Transferrin-Receptor Internalization Pathway. Small, 12(19), 2634-2640. https://doi.org/10.1002/smll.201503934

Silva, E. F. F. D., Pimenta, F. M., Pedersen, B. W., Blaikie, F. H., Bosio, G., Breitenbach, T., Westberg, M., Bregnhøj, M., Etzerodt, M., Arnaut, L. G. & Ogilby, P. R. (2016). Intracellular singlet oxygen photosensitizers: on the road to solving the problems of sensitizer degradation, bleaching and relocalization. Integrative Biology, 8(2), 177-193. https://doi.org/10.1039/C5IB00295H

Sun, M., Chen, M., Wang, M., Hansen, J., Baatrup, A., Dagnæs-Hansen, F., Rölfing, J. D., Jensen, J., Lysdahl, H., Li, H., Johannsen, M., Le, D. Q. S., Kjems, J. & Bünger, C. (2016). In vivo drug release behavior and osseointegration of a doxorubicin-loaded tissue-engineered scaffold. RSC Advances, 6(80), 76237-76245. https://doi.org/10.1039/c6ra05351c

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Kalinka Hansen