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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Vázquez-Campos, S., Péter, M., Dong, M., Xu, S., Xu, W., Gersen, H., Linderoth, T. R., Schönherr, H., Besenbacher, F., Crego-Calama, M. & Reinhoudt, D. N. (2007). Self-organization of gold-containing hydrogen-bonded rosette assemblies on graphite surface. Langmuir, 23(20), 10294-8. https://doi.org/10.1021/la701330v

Andersen, E. S., Lind-Thomsen, A., Knudsen, B., Kristensen, S. E., Havgaard, J. H., Torarinsson, E., Larsen, N., Zwieb, C., Sestoft, P., Kjems, J. & Gorodkin, J. (2007). Semiautomated improvement of RNA alignments. RNA, 13, 1850-1859.

Andersen, M. Ø., Nygaard, J. V., Howard, K., Bak, R. O., Paludan, S. R., Raarup, M. K., Besenbacher, F. & Kjems, J. (2007). Surface delivery of siRNA for implants. European Cells & Materials, 14(3), 118.

Dong, MD., Xu, S., Bünger, H., Birkedal, H. & Besenbacher, F. (2007). Temporal Assembly of Collagen Type II Studied by Atomic Force Microscopy. Advanced Engineering Materials, 9(12), 1129-1133.

Lykke-Andersen, S., Piñol-Roma, S. & Kjems, J. (2007). The human ADAR1 transcripts contain an alternative retained intron within a region that functions both as a 5'UTR and an ORF. RNA, 89(10).

Liu, X., Howard, K. A., Dong, M., Andersen, M. Ø., Rahbek, U. L., Johnsen, M. G., Hansen, O. C., Besenbacher, F. & Kjems, J. (2007). The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing. Biomaterials, 28(6), 1280-8. https://doi.org/10.1016/j.biomaterials.2006.11.004

Morgensen, JE., Ferreras, M., Wimmer, R., Petersen, S. V., Enghild, J. J. & Otzen, D. (2007). The Major Allergen from Birch Tree Pollen, Bet v 1, Binds and Permeabilizes Membranes. Biochemistry.

Novotny, G. W., Sonne, S., Nielsen, J. E., Jonstrup, S. P., Hansen, M. A., Skakkebaek, N. E., Rajpert-De Meyts, E., Kjems, J. & Leffers, H. (2007). Translational repression of E2F1 mRNA in carcinoma in situ and normal testis correlates with expression of the miR-17-92 cluster. Cell Death and Differentiation, 14(4), 879-882. https://doi.org/10.1038/sj.cdd.4402090

Mamdouh, W., Kelly, R. E. A., Dong, M., Kantorovich, L. N. & Besenbacher, F. (2007). Two-dimensional supramolecular nanopatterns formed by the coadsorption of guanine and uracil at the liquid/solid interface. Journal of the American Chemical Society, 130(2), 695-702. https://doi.org/10.1021/ja076832f

Nielsen, M. M., Andersen, K. K., Westh, P. & Otzen, D. (2007). Unfolding of ß-sheet proteins in SDS. Biophysical Journal, (92), 3674-3685.

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Kalinka Hansen