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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Kromm, F. E. H., Møller, S. L. B., Jensen, A. S., Wørmer, G. J., Rasmussen, M. H., B. Svenningsen, E., Tørring, T. & Poulsen, T. B. (2026). Modular Total Synthesis of Lasalocid Acid A through Direct C(sp³)–C(sp³) Attached Ring Construction. Journal of the American Chemical Society, 148(1), 249-257. https://doi.org/10.1021/jacs.5c11543

Ballegaard, A. S. R., Jensen, B. K., Aagaard, J. B., Miehe, M. & Spillner, E. (2026). Molecular targeting in the context of insect venom allergy: targets and perspectives. Allergo Journal International, 35(1), 8-14. https://doi.org/10.1007/s40629-025-00355-7

Aagaard, J. B., Gandini, R., Ballegaard, A.-S. R., Krogstrup Jensen, B., Dorn, B., Verner, A., Lenstrup, A., Sønderholm, M., Miehe, M., Pfützner, W., Jakob, T., Andersen, G. R., Möbs, C. & Spillner, E. (2026). Nanobody-based IgG simultaneously inhibit the allergenic and enzymatic activity of the dominant honeybee venom allergen. Nature Communications, 17(1), Article 1814. https://doi.org/10.1038/s41467-026-69572-0

Otzen, D. E., Gamon, L. F., Hägglund, P., Nielsen, J., Pedersen, J. N., Nybo, T., Nowak, J. S., Amstrup, S. K., Pirhaghi, M. & Davies, M. J. (2026). Nitrated products formed on α-synuclein are preferentially incorporated into oligomers but excluded from fibrils: A mechanism for accumulation of neurotoxic species. Biochimica et Biophysica Acta - Proteins and Proteomics, 1874(2), Article 141118. https://doi.org/10.1016/j.bbapap.2025.141118

Song, P., Su, J., Kristine Vraa, C. L., Gockert, M., Fjelstrup, S., Hager, H. & Kjems, J. (2026). Optimizing C14120-based LNPs for in vitro and in vivo mRNA delivery. Molecular Therapy Nucleic Acids, 37(1), Article 102866. https://doi.org/10.1016/j.omtn.2026.102866

Sendrowski, J. & Hobolth, A. (2026). PhaseGen: exact solutions for time-inhomogeneous multivariate coalescent distributions under diverse demographies. Genetics, 232(1), Article iyaf135. https://doi.org/10.1093/genetics/iyaf135

Hirsch, C., Lundbye, N. N. & Otto, M. (2026). Poisson approximation of large-lifetime cycles. Extremes. Advance online publication. https://doi.org/10.1007/s10687-026-00526-x

Ledderer, L. K., Nielsen, K. H., Skodborg, L. & Fage-Butler, A. (2026). Public trust and mistrust of COVID-19 vaccines: A systematic meta-narrative review. Vaccine, 69, Article 127947. https://doi.org/10.1016/j.vaccine.2025.127947

Moradzadeh, N., Jonczyk, A., Schmitz, A., Fieberg, V., Civit, L., Valero, J., Famulok, M. & Mayer, G. (2026). Selection and Characterization of SARS-CoV-2 Spike Binding Clickmers. ChemBioChem, 27(1), Article e202500733. https://doi.org/10.1002/cbic.202500733

Nielsen, K. H., Vohnsen, N. H. & Andersen, C. (2026). Strategic Skies: Denmark’s Arctic Dilemma and the Danish–Swedish Bifrost Satellite as a Case of Security Science Diplomacy. Poster session presented at AU Space Day 2026, Aarhus, Denmark.

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Kalinka Hansen