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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Nesgaard, L. W., Hoffmann, S. V., Andersen, C. B., Malmendal, A. & Otzen, D. (2008). Characterization of Dry Globular Proteins and Protein Fibrils by Synchrotron Radiation Vacuum UV Circular Dichroism. Biopolymers, 89(9), 779-795.

Hein, S., Wang, K., Stevens, W. & Kjems, J. (2008). Chitosan composites forbiomedical applications: status, challenges and perspectives. Materials Science and Technology, 24, 1053-1061. https://doi.org/10.1179/174328408X341744

Howard, K. A., Paludan, S. R., Behlke, M. A., Besenbacher, F., Deleuran, B. W. & Kjems, J. (2008). Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model. Molecular Therapy, 17(1), 162-168. https://doi.org/10.1038/mt.2008.220

Nielsen, K. H. (2008). Communicating knowledge in science, science journalism and art: The case of Gerhard Richter's Erster Blick (2000). Abstract from Encompassing knowledge: 2nd International Conference of the 360º conference series, Århus, Denmark.

Torarinsson, E., Yao, Z., Wiklund, E. D., Bramsen, J. B., Hansen, C. A., Kjems, J., Tommerup, N., Ruzzo, W. L. & Gorodkin, J. (2008). Comparative genomics beyond sequence-based alignments: RNA structures in the ENCODE regions. Genome Research, 18(2), 242-251. https://doi.org/10.1101/gr.6887408

Stissing, M., Mailund, T., Pedersen, C. S., Brodal, G. S. & Fagerberg, R. (2008). Computing the all-pairs quartet distance on a set of evolutionary trees. Journal of Bioinformatics and Computational Biology, 6(1), 37-50.

Chen, M. (2008). Conjugation of Reporter Groups and Aryltriazenes to Peptides and Oligonucleotides. Aarhus Universitetsforlag.

Chen, M. (2008). Conjugation of Reporter Groups and Aryltriazenes to Peptides and Oligonucleotides.

Fibiger, T. B. & Nielsen, K. H. (2008). Danske videnskabelige ekspeditioner: Forord. Jyske Historiker, (119).

Fibiger, T. B., Nielsen, K. H. & Petersen, R. H. (Eds.) (2008). Danske videnskabelige ekspeditioner: Den Jyske Historiker. (119 ed.) Den jyske historiker.

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Kalinka Hansen