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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Dirac, A. M., Huthoff, H., Kjems, J. & Berkhout, B. (2001). The DIS hairpin mediates dimerization of the HIV-2 RNA genome. Journal of Biological Chemistry, 276, 32345-32352.

Tange, T. Ø., Damgaard, C. K., Guth, S., Valcárcel, J. & Kjems, J. (2001). The hnRNP A1 protein regulates HIV-1 tat splicing via a novel intron silencer element. EMBO Journal, 20(20), 5748-5758. https://doi.org/10.1093/emboj/20.20.5748

Merrison, J. P., Field, D., Finster, K., Lomstein, B. A., Nørnberg, P., Ramsing, N. B. & Uggerhøj, E. (2001). The Mars Simulation Laboratory, University of Aarhus. (pp. 371-374).

Sørensen, K. B., Finster, K. & Ramsing, N. B. (2001). Thermodynamic and Kinetic Requirements in Anaerobic Methane Oxidizing Consortia Exclude Hydrogen, Acetate, and Methanol as Possible Electron Shuttles. Microb. Ecol., 42, 1-10.

Kammler, S., Leurs, C., Krummheuer, J., Seidel, K., Freund, M., Tange, T., Kjems, J., Scheid, A. & Schaal, H. (2001). The sequence complementarity of the HIV-1 5′ splice site SD4 and of U1 snRNA determines the steady-state level of an instable env pre-mRNA. RNA, 7, 421-434.

Nielsen, K. H. (2001). Vindmøller laver ikke vindkraft. In Danmarks Tekniske Museum: Årbog 2000 (Vol. 46, pp. 44-59). Danmarks Tekniske Museum.

Lund, M., Dyhr-Mikkelsen, H., Hansen, J. & Kjems, J. (2000). Characterization of human RNA splice signals by iterative functional selection of splice sites. RNA, 6, 528-544.

Madsen, N., Bowe, P., Drewsen, M., Hornekær, L., Kjærgaard, N., Labrador, A., Nielsen, J. S., Schiffer, J. P., Shi, P. & Hangst, J. S. (2000). Density distribution in laser-cooled bunched beams. Nucl. Inst. & Meth, A 441, 203.

Ebbesen, M. (2000). Det syge og det sunde. Information.

Sørensen, T. L.-M., Dupont, Y., Vilsen, B. & Andersen, J. P. (2000). Fast kinetic analysis of conformational changes in mutants of the Ca²⁺-ATPase of sarcoplasmic reticulum. Journal of Biological Chemistry, 275, 5400-5408. https://doi.org/10.1074/jbc.275.8.5400

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Kalinka Hansen