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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Tesauro, C., Simonsen, A. K., Andersen, M. B., Petersen, K. W., Kristoffersen, E. L., Algreen, L., Hansen, N. Y., Andersen, A. B., Jakobsen, A. K., Stougaard, M., Gromov, P., Knudsen, B. R. & Gromova, I. (2019). Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells: a comparative study. BMC Cancer, 19(1), Article 1158. https://doi.org/10.1186/s12885-019-6371-0

Fang, X., Wang, Z., Wang, Y., Kang, S., Jiang, Z. & Dong, M. (2019). Tuning quaternary hybride Co–Ni–S–Se composition as a bifunctional electrocatalyst for hydrogen and oxygen evolution reactions. International Journal of Hydrogen Energy, 44(51), 27685-27694. https://doi.org/10.1016/j.ijhydene.2019.08.257

van Diggelen, F., Hrle, D., Apetri, M., Christiansen, G., Rammes, G., Tepper, A. & Otzen, D. E. (2019). Two conformationally distinct α-synuclein oligomers share common epitopes and the ability to impair long-term potentiation. PLoS One, 14(3), Article 0213663. https://doi.org/10.1371/journal.pone.0213663

Jiang, H., Wang, Z., Yang, Q., Tan, L., Dong, L. & Dong, M. (2019). Ultrathin Ti ₃ C ₂ T _x (MXene) Nanosheet-Wrapped NiSe ₂ Octahedral Crystal for Enhanced Supercapacitor Performance and Synergetic Electrocatalytic Water Splitting. Nano-Micro Letters, 11(1), Article 31. https://doi.org/10.1007/s40820-019-0261-5

Bregnhøj, M., Dichmann, L., McLoughlin, C. K., Westberg, M. & Ogilby, P. R. (2019). Uric Acid: A Less-than-Perfect Probe for Singlet Oxygen. Photochemistry and Photobiology, 95(1), 202-210. https://doi.org/10.1111/php.12971

Nielsen, K. H. (2019, Apr 25). Valgkamp: Videnskaben er vigtig for politik. Videnskab.dk.

Nielsen, K. H. (2019). Vegan. Weekendavisen, Sektion 4 (Ideer), 10.

Sanchez-Weatherby, J., Sandy, J., Mikolajek, H., Lobley, C. M. C., Mazzorana, M., Kelly, J., Preece, G., Littlewood, R. & Sørensen, T. L. M. (2019). VMXi: a fully automated, fully remote, high-flux in situ macromolecular crystallography beamline. Journal of Synchrotron Radiation, 26(Part 1), 291-301. https://doi.org/10.1107/S1600577518015114

Nielsen, K. H. (2019). Vores gener. Vi er næsten ens - og så alligevel unikke. Avisen Danmark, 12.

Su, C., Yin, Z., Yan, Q. B., Wang, Z., Lin, H., Sun, L., Xu, W., Yamada, T., Ji, X., Zettsu, N., Teshima, K., Warner, J. H., Dincă, M., Hu, J., Dong, M., Su, G., Kong, J. & Li, J. (2019). Waterproof molecular monolayers stabilize 2D materials. Proceedings of the National Academy of Sciences (PNAS), 116(42), 20844-20849. https://doi.org/10.1073/pnas.1909500116

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