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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Schafer, N., Truong, H. H., Otzen, D., Lindorff-Larsen, K. & Wolynes, P. G. (2016). Topological constraints and modular structure in the folding and functional motions of GlpG, an intramembrane protease. Proceedings of the National Academy of Sciences (PNAS), 113(8), 2098-2103. https://doi.org/10.1073/pnas.1524027113

Danial, M., Halling Folkmar Andersen, A., Zuwala, K., Cosson, S., Riber, C. F., Smith, A. A. A., Tolstrup, M., Moad, G., Zelikin, A. N. & Postma, A. (2016). Triple Activity of Lamivudine Releasing Sulfonated Polymers against HIV-1. Molecular Pharmaceutics, 13(7), 2397-2410. https://doi.org/10.1021/acs.molpharmaceut.6b00156

Pérez, B., Bulsara, P., Rawlings, A. V., Wei, W., Jensen, M. M., Wang, Z., Dickens, J., Zhang, S., P. Elliot, R., Glasius, M., Dong, MD., Clarke, M. & Guo, Z. (2016). Ultralong Fatty Acyl Derivatives As Occlusive Structure Lipids for Cosmetic Applications: Synthesis and Characterization. ACS Sustainable Chemistry & Engineering, 4(12), 7137–7146. https://doi.org/10.1021/acssuschemeng.6b02021

Chen, M. (2016). Ultraporous interweaving nanofibers for tissue engineering. Abstract from Trends in Nanotechnology International Conference, Fribourg, Switzerland. http://www.tntconf.org/2016/Abstracts/2016_Chen_Menglin_menglin@inano.au.dk_TNT2016_Chen_Menglin.pdf

Nielsen, K. H. (2016). Uredelighed. Weekendavisen, Ideer, 10.

Pedersen, J. N., Frislev, H. K. S., Pedersen, J. S. & Otzen, D. E. (2016). Using protein-fatty acid complexes to improve vitamin D stability. Journal of Dairy Science, 99(10), 7755–7767. https://doi.org/10.3168/jds.2016-11343

Andersen, K. K., Vad, B. S., Roelants, S., van Bogaert, I. N. A. & Otzen, D. E. (2016). Weak and Saturable Protein-Surfactant Interactions in the Denaturation of Apo-α-Lactalbumin by Acidic and Lactonic Sophorolipid. Frontiers in Microbiology, 7(NOV), Article 1711. https://doi.org/10.3389/fmicb.2016.01711

Nielsen, K. H. (2016). What BSc students need to know about science. Poster session presented at 3rd Annual Meeting in Danish Network in Philosophy of Science, Nyborg, Denmark.

Madsen, J. K., Kaspersen, J. D., Andersen, K. K., Pedersen, J. S. & Otzen, D. E. (2016). When Enzymes and Green Surfactants Meet. Biophysical Journal, 110(3), 211A. https://doi.org/10.1016/j.bpj.2015.11.1171

Christiansen, J. R., Olesen, M. N., Otzen, D. E., Romero-Ramos, M. & Sanchez-Guajardo, V. (2016). α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology. Journal of Neuroinflammation, 13(1), Article 74. https://doi.org/10.1186/s12974-016-0532-8

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