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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Mian Teo, B., Lynge, M. E., Rigau, L. H. & Stadler, B. M. (2014). Subcompartmentalized Surface-Adhering Polymer Thin Films Toward Drug Delivery Applications. In Layer-by-Layer Films for Biomedical Applications Wiley.

Hornekær, L., Price, S. D., Mccoustra, M., Collings, M., Dulieu, F., Fillion, J. H., Palumbo, M. E., Ioppolo, S., Öberg, K. I., Linnartz, H. & Herbst, E. (2014). Surface Science. In Laboratory Astrochemistry: From Molecules through Nanoparticles to Grains (pp. 255-325). Wiley. https://doi.org/10.1002/9783527653133.ch5

Rosen, C. B., Kodal, A. L. B., Nielsen, J. S., Schaffert, D. H., Scavenius, C., Okholm, A. H., Voigt, N. V., Enghild, J. J., Kjems, J., Tørring, T. & Gothelf, K. V. (2014). Template-directed covalent conjugation of DNA to native antibodies, transferrin and other metal-binding proteins. Nature Chemistry, 6(9), 804-809. https://doi.org/10.1038/nchem.2003

Hyldgaard, M., Mygind, T., Vad, B. S., Stenvang, M., Otzen, D. & Meyer, R. L. (2014). The Antimicrobial Mechanism of Action of Epsilon-Poly-L-Lysine. Applied and Environmental Microbiology, 80(24), 7758-7770 . https://doi.org/10.1128/AEM.02204-14

Whitehead, B. J., Hvam, M. L., Bienk, K., Ostenfeld, M. S. & Howard, K. (2014). The Application of a Fluorescent Pre-Labelling Method for Evaluation of Exosome Biodistribution. Poster session presented at The 41st Annual Meeting & Exposition of the Controlled Release Society, Chicago, United States.

Olesen, M. T. J., Gonzalez, B. B. & Howard, K. (2014). The application of RNAi-based treatments for inflammatory bowel disease. Drug Delivery and Translational Research, 4(1), 4-18. https://doi.org/10.1007/s13346-013-0156-9

Andersen, E. S. (2014). The art of editing RNA structural alignments. Methods in Molecular Biology, 1097, 379-394. https://doi.org/10.1007/978-1-62703-709-9_17

Nielsen, K. H. (2014). The Emergence of Science Communication in Scandinavia. In Proceedings of PCST 2014 http://www.pcst-2014.org/pcst_proceedings/artigos/kristian_h_nielsen_panel.pdf

Sahyoun, M., Nielsen, N. W., Sørensen, J. H., Finster, K., Gosewinkel, U. B., Temkiv, T. S., Augustin, S., Hartmann, S., Niedermeier, D., Stratmann, F., Wex, H. & Korsholm, U. S. (2014). The impact of INA bacteria on ice and precipitation formation - A model study. Poster session presented at NOSA, Stockholm, Sweden.

Andreasen, M., Skeby, K. K., Zhang, S., Nielsen, E. H., Klausen, L. H., Frahm, H., Christiansen, G., Skrydstrup, T., Dong, M., Schiøtt, B. & Otzen, D. (2014). The Importance of Being Capped: Terminal Capping of an Amyloidogenic Peptide Affects Fibrillation Propensity and Fibril Morphology. Biochemistry, 53(44), 6968-6980. https://doi.org/10.1021/bi500674u

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Kalinka Hansen