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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Huma, Z.-E., Javed, I., Zhang, Z., Bilal, H., Sun, Y., Hussain, S. Z., Davis, T. P., Otzen, D. E., Landersdorfer, C. B., Ding, F., Hussain, I. & Ke, P. C. (2020). Nanosilver Mitigates Biofilm Formation via FapC Amyloidosis Inhibition. Small (Weinheim an der Bergstrasse, Germany), 16(21), Article 1906674. https://doi.org/10.1002/smll.201906674

Zhang, L., Sun, X., Jia, Y., Liu, X., Dong, M., Xu, Z. P. & Liu, R. (2020). Nanovaccine’s rapid induction of anti-tumor immunity significantly improves malignant cancer immunotherapy. Nano Today, 35, Article 100923. https://doi.org/10.1016/j.nantod.2020.100923

Walther, R., van den Akker, W., Fruergaard, A. S. & Zelikin, A. N. (2020). Nanozymes and Glucuronides: Glucuronidase, Esterase, and/or Transferase Activity. Small, 16(44), Article 2004280. https://doi.org/10.1002/smll.202004280

Santomartino, R., Waajen, A. C., de Wit, W., Nicholson, N., Parmitano, L., Loudon, C. M., Moeller, R., Rettberg, P., Fuchs, F. M., Van Houdt, R., Finster, K., Coninx, I., Krause, J., Koehler, A., Caplin, N., Zuijderduijn, L., Zolesi, V., Balsamo, M., Mariani, A. ... Cockell, C. S. (2020). No Effect of Microgravity and Simulated Mars Gravity on Final Bacterial Cell Concentrations on the International Space Station: Applications to Space Bioproduction. Frontiers in Microbiology, 11, Article 579156. https://doi.org/10.3389/fmicb.2020.579156

Alijanvand, S. H., Christensen, M. H., Christiansen, G., Harikandei, K. B., Salehi, P., Schiøtt, B., Moosavi-Movahedi, A. A. & Otzen, D. E. (2020). Novel noscapine derivatives stabilize the native state of insulin against fibrillation. International Journal of Biological Macromolecules, 147, 98-108. https://doi.org/10.1016/j.ijbiomac.2020.01.061

Basse-O’connor, A., Pedersen, J. & Rohde, V. (2020). On infinite divisibility of a class of two-dimensional vectors in the second wiener chaos. Modern Stochastics: Theory and Applications, 7(3), 267-289. https://doi.org/10.15559/20-VMSTA160

Hirsch, C. (2020). On the decomposability of mod 2 cohomological invariants of Weyl groups. Commentarii Mathematici Helvetici, 95(4), 765-809. https://doi.org/10.4171/CMH/503

Yan, Y., Chang, C., Su, J., Venø, M. T. & Kjems, J. (2020). Osteoblastogenesis Alters Small RNA Profiles in EVs Derived from Bone Marrow Stem Cells (BMSCs) and Adipose Stem Cells (ASCs). Biomedicines, 8(10), 1-17. Article 387. https://doi.org/10.3390/biomedicines8100387

Lyons, J. A., Timcenko, M., Dieudonné, T., Lenoir, G. & Nissen, P. (2020). P4-ATPases: how an old dog learnt new tricks — structure and mechanism of lipid flippases. Current Opinion in Structural Biology, 63, 65-73. https://doi.org/10.1016/j.sbi.2020.04.001

Nielsen, K. H. (2020). På den sorte liste. Weekendavisen, Sektion 4 (Ideer), 5.

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