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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Nielsen, K. H. (2016). Plast. Weekendavisen, Ideer, 10.

Andersen, A. S., Aslan, H., Dong, M., Jiang, X. & Sutherland, D. (2016). Podosome formation and development in monocytes restricted by the nanoscale spatial distribution of ICAM1. Nano Letters, 16(3), 2114-2121. https://doi.org/10.1021/acs.nanolett.6b00519

Hinton, T. M., Zuwala, K., Deffrasnes, C., Todd, S., Shi, S., Marsh, G. A., Dearnley, M., Wohl, B. M., Tolstrup, M. & Zelikin, A. N. (2016). Polyanionic Macromolecular Prodrugs of Ribavirin: Antiviral Agents with a Broad Spectrum of Activity. Advanced Healthcare Materials, 5(5), 534-540. https://doi.org/10.1002/adhm.201500841

Jensen, B. E. B., Davila, I. & Zelikin, A. N. (2016). Poly(vinyl alcohol) Physical Hydrogels: Matrix-Mediated Drug Delivery Using Spontaneously Eroding Substrate. Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical, 120(26), 5916-5926. https://doi.org/10.1021/acs.jpcb.6b01381

Frick, M., Fischer, J., Helbing, A., Ruëff, F., Wieczorek, D., Ollert, M., Pfützner, W., Müller, S., Huss-Marp, J., Dorn, B., Biedermann, T., Lidholm, J., Rücker, G., Bantleon, F., Miehe, M., Spillner, E. & Jakob, T. (2016). Predominant Api m 10 sensitization as risk factor for treatment failure in honey bee venom immunotherapy. Journal of Allergy and Clinical Immunology, 138(6), 1663-1671.e9. https://doi.org/10.1016/j.jaci.2016.04.024

Wang, J.-G., Jin, L.-N., Qian, X.-Y. & Dong, MD. (2016). Preparation and Catalytic Activity Comparison of Porous NiO, Co3O4 and NiCo2O4 Superstructures on the Thermal Decomposition of Ammonium Perchlorate. Journal of Nanoscience and Nanotechnology, 16(8), 8635-8639. https://doi.org/10.1166/jnn.2016.11635

Cheng, W., He, J., Chen, M., Li, D., Li, H., Chen, L., Cao, Y., Wang, J. & Huang, Y. (2016). Preparation, functional characterization and hemostatic mechanism discussion for oxidized microcrystalline cellulose and its composites. Fibers and Polymers, 17(8), 1277-1286. https://doi.org/10.1007/s12221-016-6279-0

Aslan, H., Krissanaprasit, A., Besenbacher, F., Gothelf, K. V. & Dong, M. (2016). Protein patterning by a DNA origami framework. Nanoscale, 8(33), 15233-15240. https://doi.org/10.1039/C6NR03199D

Nielsen, K. H. (2016). Qbit. Weekendavisen, Ideer, 10.

Nielsen, K. H. (2016). Radikalisering. Weekendavisen, Ideer, 10.

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Kalinka Hansen