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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Rigau, L. H. & Stadler, B. M. (2013). Subcompartmentalized Systems Towards Therapeutic Cell Mimics. In T. M. S. Chang (Ed.), Selected Topics in Nanomedicine (pp. 281-299). World Scientific. https://doi.org/10.1142/9789814472869_0012

Múzquiz, M. S., Bøjesen, E. D., Song, J., Dong, M. & Christensen, M. (2013). Supercritical ﬂow synthesis of Sr-hexaferrite.

Ebbesen, M. F., Whitehead, B. J., Gonzalez, B. B., Kingshott, P. & Howard, K. (2013). Surface analysis of PEGylated nano-shields on nanoparticles installed by hydrophobic anchors. Pharmaceutical Research, 30(7), 1758-1767. https://doi.org/10.1007/s11095-013-1018-3

Chernyy, S., Jensen, B. E. B., Shimizu, K., Ceccato, M., Pedersen, S. U., Zelikin, A. N., Daasbjerg, K. & Iruthayaraj, J. (2013). Surface Grafted Glycopolymer Brushes to Enhance Selective Adhesion of HepG2 Cells. Journal of Colloid and Interface Science, 404, 207–214. https://doi.org/10.1016/j.jcis.2013.04.025

Ebbesen, M. F., Schaffert, D. H., Crowley, M. L., Oupický, D. & Howard, K. (2013). Synthesis of click-reactive HPMA copolymers using RAFT polymerization for drug delivery applications. Journal of Polymer Science. Part A, Polymer Chemistry, 51(23), 5091-5099. https://doi.org/10.1002/pola.26941

Hansen, L., Unmack Larsen, E. K., Nielsen, E. H., Iversen, F., Liu, Z., Thomsen, K., Pedersen, M., Skrydstrup, T., Nielsen, N. C., Ploug, M. & Kjems, J. (2013). Targeting of peptide conjugated magnetic nanoparticles to urokinase plasminogen activator receptor (uPAR) expressing cells. Nanoscale, 5, 8192-8201. https://doi.org/10.1039/c3nr32922d

Juul, S., Iacovelli, F., Falconi, M., Kragh, S. L., Christensen, B. S., Hougaard, R. F., Franch, O., Kristoffersen, E. L., Stougaard, M., Leong, K. W., Ho, Y.-P., Sørensen, E. S., Birkedal, V., Desideri, A. & Knudsen, B. R. (2013). Temperature-Controlled Encapsulation and Release of an Active Enzyme in the Cavity of a Self-Assembled DNA Nanocage. ACS Nano, 7(11), 9724-9734. https://doi.org/10.1021/nn4030543

Helwig, M., Hoshino, A., Berridge, C., Lee, S.-N., Lorenzen, N., Otzen, D., Eriksen, J. & Lindberg, I. (2013). The neuroendocrine protein 7B2 suppresses the aggregation of neurodegenerative disease-related proteins. Journal of Biological Chemistry, 288(2), 1114.

Bayraktarov, E., Price, R. E., Ferdelman, T. G. & Finster, K. (2013). The pH and pCO₂ dependence of sulfate reduction in shallow-seahydrothermal CO₂– venting sediments (Milos Island,Greece). Frontiers in Microbiology, 4, Article 111. https://doi.org/10.3389/fmicb.2013.00111

Panpipat, W., Dong, M., Xu, X. & Guo, Z. (2013). Thermal properties and nanodispersion behavior of synthesized β-sitosteryl acyl esters: A structure-activity relationship study. Journal of Colloid and Interface Science, 407, 177-186. https://doi.org/10.1016/j.jcis.2013.06.030

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Kalinka Hansen