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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Wohl, B., Smith, A. A. A., Jensen, B. E. B. & Zelikin, A. N. (2014). Macromolecular (pro)drugs with concurrent direct activity against the hepatitis C virus and inflammation. Journal of Controlled Release, 196, 197–207. https://doi.org/10.1016/j.jconrel.2014.09.032

Hobolth, A. & Jensen, J. L. (2014). Markovian approximation to the finite loci coalescent with recombination along multiple sequences. Theoretical Population Biology, 98, 48-58. https://doi.org/10.1016/j.tpb.2014.01.002

Gao, S., Hein, S., Dagnæs-Hansen, F., Weyer, K., Yang, C., Nielsen, R., Christensen, E. I., Fenton, R. A. & Kjems, J. (2014). Megalin-Mediated Specific Uptake of Chitosan/siRNA Nanoparticles in Mouse Kidney Proximal Tubule Epithelial Cells Enables AQP1 Gene Silencing. Theranostics, 4(10), 1039-51. https://doi.org/10.7150/thno.7866

Otzen, D. (2014). Membrane protein folding and stability. Archives of Biochemistry and Biophysics, 564, 262-264. https://doi.org/10.1016/j.abb.2014.10.014

Santl-Temkiv, T., Sahyoun, M., Kjeldsen, H., Ling, M., Boesen, T., Karlson, U. G. & Finster, K. (2014). Microbial production of ice crystals in clouds as a novel atmospheric biosignature.

Hansen, T. B., Venø, M. T., Kjems, J. & Damgaard, C. K. (2014). miRdentify: high stringency miRNA predictor identifies several novel animal miRNAs. Nucleic Acids Research, 42(16), 1-11. Article e124. https://doi.org/10.1093/nar/gku598

Nielsen, K. H. (2014). Moder natur som våben. Videnskab.dk. http://videnskab.dk/blog/moder-natur-som-vaben

Li, Q., Liu, L., Zhang, S., Xu, M., Wang, X., Wang, C., Besenbacher, F. & Dong, MD. (2014). Modulating Aβ_33-42 Peptide Assembly by Graphene Oxide. Chemistry: A European Journal, 20(24), 7236-7240. https://doi.org/10.1002/chem.201402022

Ling, M., Santl-Temkiv, T., Finster, K. & Boesen, T. (2014). Molecular and physical characterization of bacterial ice nucleation proteins provide an insight into their biosignature potential.. Poster session presented at Joint Meeting of the Nordic Network of Astrobiology and the Centre of Geobiology, University of Bergen, Bergen, Norway.

Liu, L., Niu, L., Xu, M., Han, Q., Duan, H., Dong, MD., Besenbacher, F., Wang, C. & Yang, Y. (2014). Molecular Tethering Effect of C-Terminus of Amyloid Peptide Aβ42. A C S Nano, 8(9), 9503-9510. https://doi.org/10.1021/nn503737r

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Kalinka Hansen