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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Christensen, L. F. B., Hansen, L. M., Finster, K., Christiansen, G., Nielsen, P. H., Otzen, D. E. & Dueholm, M. S. (2018). The Sheaths of Methanospirillum Are Made of a New Type of Amyloid Protein. Frontiers in Microbiology, 9(NOV), Article 2729. https://doi.org/10.3389/fmicb.2018.02729, https://doi.org/10.3389/fmicb.2018.02729

Madsen, J. K., Giehm, L. & Otzen, D. E. (2018). The Use of Surfactants to Solubilise a Glucagon Analogue. Pharmaceutical Research, 35(12), Article 235. https://doi.org/10.1007/s11095-018-2494-2

Olsen, M. & Andersen, L. N. (2018). Towards Asymptotically Optimal One-to-One PDP Algorithms for Capacity 2+ Vehicles. In Computational Logistics - 9th International Conference, ICCL 2018, Proceedings (pp. 268-278). Springer. https://doi.org/10.1007/978-3-030-00898-7_17

Jabs, F., Plum, M., Laursen, N. S., Jensen, R. K., Mølgaard, B., Miehe, M., Mandolesi, M., Rauber, M. M., Pfützner, W., Jakob, T., Möbs, C., Andersen, G. R. & Spillner, E. (2018). Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction. Nature Communications, 9(1), Article 7. https://doi.org/10.1038/s41467-017-02312-7

Liu, L., Klausen, L. H. & Dong, M. (2018). Two-dimensional peptide based functional nanomaterials. Nano Today, 23, 40-58. https://doi.org/10.1016/j.nantod.2018.10.008

Agergaard, T. E. & Nielsen, K. H. (2018). Uenighed: Ansigt på usikkerheden. In M. A. Skydsgaard & K. H. Nielsen (Eds.), Videnskab er lidenskab: Med forskere på arbejde (pp. 67-83). Aarhus Universitetsforlag.

Frislev, H. S., Nielsen, J., Nylandsted, J. & Otzen, D. (2018). Using Liprotides to Deliver Cholesterol to the Plasma Membrane. Journal of Membrane Biology, 25(4), 581-592. https://doi.org/10.1007/s00232-018-0034-y

Nielsen, K. H. (2018). Vandmøllen har været afgørende for samfundets udvikling. Videnskab.dk. https://videnskab.dk/teknologi-innovation/vandmoellen-har-vaeret-afgoerende-for-samfundets-udvikling

Riverol, A. P., Miehe, M., Jabs, F., Seismann, H., Romani Fernandes, L. G., de Lima Zollner, R., Jakob, T., Brochetto-Braga, M. R. & Spillner, E. (2018). Venoms of Neotropical wasps lack cross-reactive carbohydrate determinants enabling reliable protein-based specific IgE determination. Journal of Allergy and Clinical Immunology, 141(5), 1917-1919.e1. https://doi.org/10.1016/j.jaci.2017.12.990

Skydsgaard, M. A. & Nielsen, K. H. (Eds.) (2018). Videnskab er lidenskab: Med forskere på arbejde. Aarhus Universitetsforlag.

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