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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Andersen, E. S., Kjems, J., Thostrup, P. & Besenbacher, F. (2004). Case study: HIVs hemmelige sexliv. Biozoom, 7(4), 23-25.

Abildgaard, L., Ramsing, N. B. & Finster, K. (2004). Characterization of the marine propionate-degrading, sulfate-reducing bacterium Desulfofaba fastidiosa sp. nov. and reclassification of Desulformusa hansenii as Desulfofaba hansenii comb.nov. Int. J. Syst. Evol. Microbiol., 54, 393-399.

Kölln, J., Spillner, E., Andrä, J., Klensang, K. & Bredehorst, R. (2004). Complement inactivation by recombinant human C3 derivatives. Journal of Immunology, 173(9), 5540-5.

Richardson, K., Grønkjær, P. & Andersen, E. S. (2004). Dansk fiskeri - i klemme mellem klima og kvoter. Aktuel Naturvidenskab, 2, 13-16.

Klostergaard, L., Nielsen, K. H., Brock, S. (Ed.) & Aagaard, L. (Ed.) (2004). Darwins rejse: Videnskabshistorie og videnskabelig refleksivitet. In Videnskabens ansigter (pp. 249-263). Forlaget Philosophia.

Olesen, C., Sørensen, T. L.-M., Nielsen, R. C., Møller, J. V. & Nissen, P. (2004). Dephosphorylation of the Calcium Pump Coupled to Counterion Occlusion. Science, 306, 2251-2255.

Shlimon, A. G., Friedrich, M. W., Niemann, H., Ramsing, N. B. & Finster, K. (2004). Methanobacterium aarhusense sp. nov., a novel methanogen isolated from a marine sediment (Aarhus Bay, Denmark). Int. J. Syst. Evol. Microbiol., 54, 759-763.

Knudsen, B., Andersen, E. S., Damgaard, C. K., Kjems, J. & Gorodkin, J. (2004). Evolutionary rate variation and RNA secondary structure prediction. Computational Biology and Chemistry, 28(3), 219-26. https://doi.org/10.1016/j.compbiolchem.2004.04.001

Nielsen, K. H. (2004). Forskning, formidling og forståelse. Biozoom.

Kölln, J., Matzas, M., Jänner, N., Mix, T., Klensang, K., Bredehorst, R. & Spillner, E. (2004). Functional analysis of Cobra Venom Factor/human C3 chimeras transiently expressed in mammalian cells. Molecular Immunology, 41(1), 19-28. https://doi.org/10.1016/j.molimm.2004.02.003

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Kalinka Hansen