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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Klein, W. P., Thomsen, R. P., Turner, K. B., Walper, S. A., Vranish, J., Kjems, J., Ancona, M. G. & Medintz, I. L. (2019). Enhanced Catalysis from Multienzyme Cascades Assembled on a DNA Origami Triangle. ACS Nano, 13(12), 13677-13689. https://doi.org/10.1021/acsnano.9b05746

Wang, J., Zhang, Z., Zhang, H., Li, C., Chen, M., Liu, L. & Dong, M. (2019). Enhanced Photoresponsive Graphene Oxide-Modified g-C ₃ N ₄ for Disassembly of Amyloid β Fibrils. ACS Applied Materials & Interfaces, 11(1), 96-103. https://doi.org/10.1021/acsami.8b10343

Neumann, M., Hirsch, C., Staněk, J., Beneš, V. & Schmidt, V. (2019). Estimation of geodesic tortuosity and constrictivity in stationary random closed sets. Scandinavian Journal of Statistics, 46(3), 848-884. https://doi.org/10.1111/sjos.12375

Nielsen, K. H. (2019). Europa. Weekendavisen, Sektion 4 (Ideer), 10.

Leunbach, R. N. & Nielsen, K. H. (2019). Exploring the Dialogical Space of Hybrid Forums: The “Predictably Unpredictable” Case of Radioactive Waste Management in Denmark, 2003-2018. Bulletin of Science, Technology & Society, 39(1-2), 4-18. https://doi.org/10.1177/0270467620932831

Walther, R., Olesen, M. T. J. & Zelikin, A. N. (2019). Extended scaffold glucuronides: en route to the universal synthesis of O-aryl glucuronide prodrugs. Organic and Biomolecular Chemistry, 17(29), 6970-6974. https://doi.org/10.1039/c9ob01384a

Zhao, H., Yang, Q., Wang, Z., Zhao, H., Liu, B., Chen, Q. & Dong, M. (2019). Fabrication of 2D Hetero-Complexes With Nucleic-Acid-Base Adenine and Fatty-Acid Stearic Acid at Liquid/Solid Interface. Frontiers in Chemistry, 7, Article 513. https://doi.org/10.3389/fchem.2019.00513, https://doi.org/10.3389/fchem.2019.00513

Garcia, JP., Stein, J., Cai, Y., Riemers, F., Wexselblatt, E., Wengel, J., Tryfonidou, M., Yayon, A., Howard, K. & Creemers, L. B. (2019). Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis. Journal of Controlled Release, 294, 247-258. https://doi.org/10.1016/j.jconrel.2018.12.030

Schiølin, K. & Baskin, J. (2019, Oct 28). Fourth Industrial Revolution: The revolution from above – a comparison of SA and Denmark. Daily Maverick. https://www.dailymaverick.co.za/article/2019-10-28-fourth-industrial-revolution-the-revolution-from-above-a-comparison-of-sa-and-denmark/

Otzen, D. & Riek, R. (2019). Functional Amyloids. Cold Spring Harbor Perspectives in Biology, 11(12), Article a033860. https://doi.org/10.1101/cshperspect.a033860

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Kalinka Hansen