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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Ebbesen, M. F., Olesen, M. T. J., Gjelstrup, M. C., Pakula, M. M., Larsen, E. K., Hansen, I. M., Hansen, P. L., Mollenhauer, J., Malle, B. M. & Howard, K. (2015). Tunable CD44-Specific Cellular Retargeting with Hyaluronic Acid Nanoshells. Pharmaceutical Research, 32(4), 1462-1474. https://doi.org/10.1007/s11095-014-1552-7

Li, Q., Song, J., Besenbacher, F. & Dong, MD. (2015). Two-dimensional material confined water published as part of the accounts of chemical research special issue "2d nanomaterials beyond Graphene". Accounts of Chemical Research, 48(1), 119-127. https://doi.org/10.1021/ar500306w

Peng, Z., Hou, X., Liu, L., Mi, J. & Dong, M. (2015). Two-Dimensional π-Conjugated Metal Bis(dithiolene) Complex Nanosheets as Selective Catalysts for Oxygen Reduction Reaction. The Journal of Physical Chemistry Part C, 119(50), 28028-28037. https://doi.org/10.1021/acs.jpcc.5b09148

Eriksen, C. B. (2015, Jan 11). Tyngdekraft, naturhistorie, revolution. http://baggrund.com/tyngdekraft-naturhistorie-revolution/

Li, Y., Gregersen, H. V., Nygaard, J. V., Cheng, W., Yu, Y., Huang, Y., Dong, M., Besenbacher, F. & Chen, M. (2015). Ultraporous nanofeatured PCL–PEO microfibrous scaffolds enhance cell infiltration, colonization and myofibroblastic differentiation. Nanoscale, 7(36), 14989-14995. https://doi.org/10.1039/c5nr04244e

Yang, C., Thomsen, R. P., Ogaki, R., Kjems, J. & Mian Teo, B. (2015). Ultrastable green fluorescence carbon dots with a high quantum yield for bioimaging and use as theranostic carriers. Journal of Materials Chemistry B, 3(4577), 4577-4584. https://doi.org/10.1039/C5TB00467E

Nielsen, K. H. (2015). Vandmøllen. In H. Kragh & K. H. Nielsen (Eds.), 50 opfindelser: Højdepunkter i teknologien (pp. 29-33). Aarhus Universitetsforlag.

Nielsen, K. H. & Heymann, M. (2015). Vil politikerne svigte klimaet igen? Politiken, Debat, 12.

Nielsen, K. H. (2015). Vindmøllen. In H. Kragh & K. H. Nielsen (Eds.), 50 opfindelser: Højdepunkter i teknologien (pp. 225-229). Aarhus Universitetsforlag.

Nielsen, K. H. (2014). 10 års ESOF. Videnskab.dk. http://videnskab.dk/blog/10-ars-esof

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