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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Stissing, M., Mailund, T., Pedersen, C. N. S., Brodal, G. S. & Fagerberg, R. (2007). Computing the All-Pairs Quartet Distance on a Set of Evolutionary Trees. In Proceedings of the 5th Asia-Pacific Bioinformatics Conference (APBC) (pp. 91-100)

Stissing, M., Pedersen, C. N. S., Mailund, T. & Brodal, G. S. (2007). Computing the Quartet Distance between Evolutionary Trees of Bounded Degree. In Proceedings of the 5th Asia-Pacific Bioinformatics Conference (APBC) (pp. 101-110)

Dong, M., Xu, S., Oliveira, C., Pedersen, J. S., Thiel, S., Besenbacher, F. & Vorup-Jensen, T. (2007). Conformational changes in mannan-binding lectin bound to ligand surfaces. The Journal of Immunology, 178, 3016-3022.

Dong, M., Xu, S., Oliveira, C. L. P., Pedersen, J. S., Thiel, S., Besenbacher, F. & Vorup-Jensen, T. (2007). Conformational changes in mannan-binding lectin bound to ligand surfaces. Journal of Immunology, 178(5), 3016-22.

Morth, J. P., Pedersen, B. P., Toustrup-Jensen, M. S., Sørensen, T. L.-M., Petersen, J., Andersen, J. P., Vilsen, B. & Nissen, P. (2007). Crystal structure of the sodium-potassium pump. Nature, 450(7172), 1043-1049. https://doi.org/10.1038/nature06419

Xu, W., Dong, M., Gersen, H., Rauls, E., Vázquez-Campos, S., Crego-Calama, M., Reinhoudt, D. N., Stensgaard, I., Laegsgaard, E., Linderoth, T. R. & Besenbacher, F. (2007). Cyanuric acid and melamine on Au111: structure and energetics of hydrogen-bonded networks. Small, 3(5), 854-8. https://doi.org/10.1002/smll.200600407

Heegaard, P. M. P., Boas, U. & Otzen, D. (2007). Dendrimer effects on peptide and protein fibrillation. Macromolecular Bioscience, (7), 1047-1059.

Nielsen, K. H. (2007). Den store fortælling om naturvidenskab: Boganm: Robin Engelhardt og Hans Siggaard Jensen: ERGO. Naturvidenskabens filosofiske udvikling. Information, 36.

Xu, S., Dong, M., Liu, X., Howard, K. A., Kjems, J. & Besenbacher, F. (2007). Direct force measurements between siRNA and chitosan molecules using force spectroscopy. Biophysical Journal, 93(3), 952-9. https://doi.org/10.1529/biophysj.106.093229

Jakobsen, M. R., Haasnoot, J., Wengel, J., Berkhout, B. & Kjems, J. (2007). Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites. Retrovirology, 4(29), 1-13. https://doi.org/10.1186/1742-4690-4-29

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Kalinka Hansen