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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Li, Z., Hu, Y., Chang, M., Howard, K., Fan, X., Sun, Y., Besenbacher, F. & Yu, M. (2016). Highly porous PEGylated Bi2S3 nano-urchins as a versatile platform for in vivo triple-modal imaging, photothermal therapy and drug delivery. Nanoscale, 8(35), 16005-16016. https://doi.org/10.1039/C6NR03398A

Zuwala, K., Smith, A. A. A., Tolstrup, M. & Zelikin, A. N. (2016). HIV anti-latency treatment mediated by macromolecular prodrugs of histone deacetylase inhibitor, panobinostat. Chemical Science, 7(3), 2353-2358. https://doi.org/10.1039/c5sc03257a

Malmos, K. G., Bjerring, M., Jessen, C. M., Nielsen, E. H. T., Poulsen, E. T., Christiansen, G., Vosegaard, T., Skrydstrup, T., Enghild, J. J., Pedersen, J. S. & Otzen, D. E. (2016). How Glycosaminoglycans Promote Fibrillation of Salmon Calcitonin. Journal of Biological Chemistry, 291(32), 16849-16862. https://doi.org/10.1074/jbc.M116.715466

Nielsen, K. H. (2016). How User Assemblage Matters: Constructing Learning by Using in the Case of Wind Turbine Technology in Denmark, 1973-1990. In S. Hyysalo, T. Elgaard Jensen & N. Oudshoorn (Eds.), The New Production of Users: Changing Innovation Collectives and Involvement Strategies (pp. 101-122). Routledge. https://doi.org/10.4324/9781315648088

Bantleon, F., Wolf, S., Seismann, H., Dam, S. S., Lorentzen, A., Miehe, M., Jabs, F., Jakob, T., Plum, M. & Spillner, E. (2016). Human IgE is efficiently produced in glycosylated and biologically active form in lepidopteran cells. Molecular Immunology, 72, 49-56. https://doi.org/10.1016/j.molimm.2016.02.013

Li, Z., Hu, Y., Jiang, T., Howard, K., Li, Y., Fan, X., Sun, Y., Besenbacher, F. & Yu, M. (2016). Human serum albumin coated Prussian blue nanoparticles as pH-/thermo-triggered drug delivery vehicles for cancer thermo-chemotherapy. Particle & Particle Systems Characterization, 33(1), 53-62. https://doi.org/10.1002/ppsc.201500189

Offermann, N., Plum, M., Hübner, U., Rathloff, K., Braren, I., Fooke, M. & Spillner, E. (2016). Human serum substitution by artificial sera of scalable allergen reactivity based on polyclonal antibodies and chimeras of human FcγRI and IgE domains. Allergy: European Journal of Allergy and Clinical Immunology, 71(12), 1794-1799. https://doi.org/10.1111/all.13038

Hobolth, A. (2016). Hvem er bedst? metoder til rangering i sport og videnskab. Aktuel Naturvidenskab, 5, 26-29.

Schiølin, K. H. (2016). Hvis vi vil forstå os selv, må vi prøve at forstå teknologien. Jyllands-Posten, Indblik, (03.10.2016 ), 12-13.

Nielsen, K. H. (2016). Hvordan skal æren for videnskabelige publikationer fordeles? Videnskab.dk.

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Kalinka Hansen