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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Hansen, T. B., Venø, M. T., Jensen, T. I., Schaefer, A., Damgaard, C. K. & Kjems, J. (2016). Argonaute-associated short introns are a novel class of gene regulators. Nature Communications, 7, Article 11538. https://doi.org/10.1038/ncomms11538

Cheng, W., Xu, R., Li, D., Bortolini, C., He, J., Dong, MD., Besenbacher, F., Huang, Y. & Chen, M. (2016). Artificial extracellular matrix delivers TGFb1 regulating myofibroblast differentiation. RSC Advances, 6(26), 21922-21928. https://doi.org/10.1039/c5ra26164c

Neuhäuser, D., Hirsch, C., Gloaguen, C. & Schmidt, V. (2016). A stochastic model for multi-hierarchical networks. Methodology and Computing in Applied Probability, 18(4), 1129-1151.

Kristoffersen, E. L. (2016). A Study of Designed DNA Nanostructures and their use in Enzyme Activity Detection.

Nielsen, K. H. & Kjærgaard, A. L. (2016). At se og fejle som en velfærdsstat: Moderniseringsbestræbelser og -problemer i Grønland efter anden verdenskrig. TEMP. Tidsskrift for historie, (12), 41-58.

Nielsen, K. H. (2016). Bevidsthed. Weekendavisen, Ideer, 10.

Ebbesen, M. (2016). Bioethics across Cultures – Philosophical and Empirical Justification of the Four Principles of Biomedical Ethics. Journal of Clinical Research and Bioethics, 7(1), 259-261. https://doi.org/10.4172/2155-9627.1000259

Liang, C., Hu, Y., Wang, H., Xia, D., Li, Q., Zhang, J., Yang, J., Li, B., Li, H., Han, D. & Dong, M. (2016). Biomimetic cardiovascular stents for in vivo re-endothelialization. Biomaterials, 103, 170-182. https://doi.org/10.1016/j.biomaterials.2016.06.042

Nielsen, K. H. (2016). Bit. Weekendavisen, Ideer, 10.

Nielsen, K. H. (2016). Bitcoin. Weekendavisen, Ideer, 10.

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