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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Recent publications by network

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Hornekær, L., Drewsen, M., Brodersen, C., Schiffer, J. P. & Hangst, J. S. (1998). Ion crystals in a linear Paul trap. Hyperfine Interactions, 115, 37-40.

Drewsen, M., Brodersen, C., Hornekær, L., Hangst, J. S. & Schiffer, J. P. (1998). Large ion crystals in a linear paul trap. Physical Review Letters, 81(14), 2878-2881.

Damgaard, C. K., Dyhr-Mikkelsen, H. & Kjems, J. (1998). Mapping the RNA binding sites for human immunodeficiency virus type-1 gag and NC proteins within the complete HIV-1 and -2 untranslated leader regions. Nucleic Acid Research, 26(16).

Nielsen, K. H. (1998). Richard L. Hills, Power from Wind. A History of Windmill Technology. Cambridge etc. (Cambridge University Press) 1996. Centaurus (Copenhagen), 40, 398-399.

Blaabjerg, V. & Finster, K. (1998). Sulphate reduction associated with roots and rhizomes of the marine macrophyte Zostera marina. Aquatic Microbial Ecology, 15(3), 311-314. https://doi.org/10.3354/ame015311

Finster, K., Coates, J. D., Liesack, W. & Pfennig, N. (1997). Desulfuromonas thiophila sp. nov., a new obligately sulfur-reducing bacterium from anoxic freshwater sediment. International Journal of Systematic Bacteriology, 47(3), 754-8.

Lykke-Andersen, J., Garrett, R. A. & Kjems, J. (1997). Mapping metal ions at the catalytic centres of two intron-encoded endonucleases. EMBO Journal, 16(11), 3272-3281. https://doi.org/10.1093/emboj/16.11.3272

Liebau, E., Spillner, E. & Henkle-Dührsen, K. (1997). pOVEX vector: Prokaryotic expression and purification of onchocerciasis vaccine candidate antigens as fusion proteins with the 24 kD Onchocerca volvulus glutathione S-transferase. Tropical Medicine & International Health, 2(7), 691-694.

Finster, K., Liesack, W. & Tindall, B. J. (1997). Sulfurospirillum arcachonense sp. nov., a new microaerophilic sulfur-reducing bacterium. International Journal of Systematic Bacteriology, 47(4), 1212-7.

Rysgaard, S., Finster, K. & Dahlgaard, H. (1996). Primary production, nutrient dynamics and mineralisationin a northeastern greenland fjord during the summer thaw. Polar Biology, 16(7), 497-506. https://doi.org/10.1007/BF02329069, https://doi.org/10.1007/s003000050081

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Kalinka Hansen