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Recent research news on Artificial Biology

27 November 2023 - Research news

In this work, synthetic cells equipped with an artificial signaling pathway that connects an extracellular trigger event to the activation of intracellular transcription are engineered. Learning from nature, this is done via an engineering of responsive enzymes, such that activation of enzymatic activity can be triggered by an external biochemical stimulus. Reversibly deactivated creatine kinase to achieve triggered production of adenosine triphosphate, and a reversibly deactivated nucleic acid…

01 May 2023 - Research news

Nanopores are label-free single-molecule analytical tools that show great potential for stochastic sensing of proteins. Here, we described a ClyA nanopore functionalized with different nanobodies through a 5–6 nm DNA linker at its periphery. Ty1, 2Rs15d, 2Rb17c, and nb22 nanobodies were employed to specifically recognize the large protein SARS-CoV-2 Spike, a medium-sized HER2 receptor, and the small protein murine urokinase-type plasminogen activator (muPA), respectively. The pores modified with…

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Smith, A. A. A., Zuwala, K., Kryger, M., Wohl, B., Guerrero-Sanchez, C., Tolstrup, M., Postma, A. & Zelikin, A. N. (2015). Macromolecular prodrugs of ribavirin: towards a treatment for co-infection with HIV and HCV. Chemical Science, 6(1), 264-269. https://doi.org/10.1039/C4SC02754J

Ma, Z., Dagnaes-Hansen, F., Løvschall, H., Song, W., Nielsen, G. K., Yang, C., Wang, Q., Kjems, J. & Gao, S. (2015). Macrophage-mediated nanoparticle delivery to the periodontal lesions in established murine model via Pg-LPS induction. Journal of Oral Pathology & Medicine, 44(7), 538-542. https://doi.org/10.1111/jop.12269

Klausen, L. H., Fuhs, T., Besenbacher, F. & Dong, M. (2015). Mapping surface charge density with a scanning nanopipette. American Physical Society. Bulletin, 60(1), A21.00003. http://meeting.aps.org/Meeting/MAR15/Session/A21.3

Nielsen, K. H. (2015). Maskingeværet. In H. Kragh & K. H. Nielsen (Eds.), 50 opfindelser: Højdepunkter i teknologien (pp. 99-103). Aarhus Universitetsforlag.

Bortolini, C., Jones, N. C., Hoffmann, S. V., Wang, C., Besenbacher, F. & Dong, M. (2015). Mechanical properties of amyloid-like fibrils defined by secondary structures. Nanoscale, 7, 7745-7752. https://doi.org/10.1039/C4NR05109B

Zhang, L., Feng, Q., Wang, J., Zhang, S., Ding, B., Wei, Y., Dong, M., Ryu, J. Y., Yoon, T. Y., Shi, X., Sun, J. & Jiang, X. (2015). Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell-Nanoparticle Interaction. ACS Nano, 9(10), 9912-9921. https://doi.org/10.1021/acsnano.5b05792

Jensen, B. E. B., Edlund, K. & Zelikin, A. N. (2015). Micro-structured, spontaneously eroding hydrogels accelerate endothelialization through presentation of conjugated growth factors. Biomaterials, 49, 113-124. https://doi.org/10.1016/j.biomaterials.2015.01.036

Jin, L.-N., Qian, X.-Y., Wang, J.-G., Aslan, H. & Dong, M. (2015). MIL-68 (In) nano-rods for the removal of Congo red dye from aqueous solution. Journal of Colloid and Interface Science, 453, 270-275. https://doi.org/10.1016/j.jcis.2015.05.005

Nielsen, K. H. (2015). Militæret hjalp Apple og Steve Jobs til succes. Videnskab.dk. http://videnskab.dk/teknologi/militaeret-hjalp-apple-og-steve-jobs-til-succes

Zhang, Y., Lynge, M. E., Mian Teo, B., Ogaki, R. & Stadler, B. M. (2015). Mixed Poly(dopamine)/Poly(L lysine) (Composite) Coatings: From Assembly to Interaction with Endothelial Cells. Biomaterials Science, 3, 1188-1196. https://doi.org/10.1039/C5BM00093A

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